Rabbit NFKBIZ Polyclonal Antibody | anti-NFKBIZ antibody

NFKBIZ Polyclonal Antibody

Cat. Num. AAA2547713

• Gene Names: NFKBIZ; IKBZ; INAP; MAIL
• Applications: Western Blot
• Synonyms: NFKBIZ; Polyclonal Antibody; NFKBIZ Polyclonal Antibody; anti-NFKBIZ antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Sequence Length: 618

• Applicable Applications for anti-NFKBIZ antibody: Western Blot (WB)
• Application Notes: WB: 1:1000 - 1:2000
• Immunogen: Recombinant protein of human NFKBIZ
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 53832024
• NCBI GeneID: 64332
• NCBI Accession #: NP_001005474.1
• NCBI GenBank Nucleotide #: NM_001005474.2
• UniProt Accession #: Q9BYH8; Q8IUL4; Q8NAZ8; B3KNR2; D3DN54
• Molecular Weight: 78kDa
• NCBI Official Full Name: NF-kappa-B inhibitor zeta isoform b
• NCBI Official Synonym Full Names: NFKB inhibitor zeta
• NCBI Official Symbol: NFKBIZ
• NCBI Official Synonym Symbols: IKBZ; INAP; MAIL
• NCBI Protein Information: NF-kappa-B inhibitor zeta
• UniProt Protein Name: NF-kappa-B inhibitor zeta
• Protein Family: NF-kappa-B inhibitor
• UniProt Gene Name: NFKBIZ
• UniProt Synonym Gene Names: IKBZ; INAP; MAIL; IkB-zeta; IkappaBzeta; INAP; MAIL

NCBI Description

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

IkB-zeta: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. Interacts with NFKB1/p50. Interacts with RELA. By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS). Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 3q12.3

Cellular Component: nuclear speck; nucleus

Molecular Function: protein binding; transcription cofactor activity

Biological Process: regulation of transcription from RNA polymerase II promoter