Goat NFATC4/NFAT3 Polyclonal Antibody | anti-NFATC4 antibody
Goat anti-NFATC4/NFAT3 Antibody
Western Blot: Preliminary experiments in Human Heart, Jurkat and MOLT-4 lysates gave no specific signal but low background (at antibody concentration up to 0.5ug/ml).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Description
NFAT3: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. 23 alternatively spliced isoforms of the human protein hve been reported.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cytoplasm; cytosol; intermediate filament cytoskeleton; nucleus; transcription factor complex
Molecular Function: peroxisome proliferator activated receptor binding; protein binding; transcription coactivator activity; transcription factor binding
Biological Process: calcineurin-NFAT signaling pathway; cellular respiration; DNA damage response, signal transduction resulting in induction of apoptosis; heart development; inflammatory response; muscle cell development; negative regulation of dendrite morphogenesis; negative regulation of protein binding; negative regulation of Wnt receptor signaling pathway; patterning of blood vessels; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of synaptic plasticity; smooth muscle cell differentiation; transcription from RNA polymerase II promoter
Research Articles on NFATC4
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Product Notes
The NFATC4 nfatc4 (Catalog #AAA422001) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-NFATC4/NFAT3 Antibody reacts with Expected from sequence similarity: Human, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's NFATC4/NFAT3 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Preliminary experiments in Human Heart, Jurkat and MOLT-4 lysates gave no specific signal but low background (at antibody concentration up to 0.5ug/ml). Researchers should empirically determine the suitability of the NFATC4 nfatc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: EATVNRLQSN EVTLT. It is sometimes possible for the material contained within the vial of "NFATC4/NFAT3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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