Rabbit anti-Human Neurotensin Polyclonal Antibody | anti-NTS antibody

Neurotensin, NT (Human Proneurotensin, Large Neuromedin N, Neuromedin N Preproprotein, NMN-125, NN, NT, NT/N, NTRH, NTS, NTS1, Proneuromedin N mRNA, Tail Peptide)

Cat. Num. AAA621740

• Gene Names: NTS; NN; NT; NT/N; NTS1; NMN-125
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: Neurotensin; Polyclonal Antibody; NT (Human Proneurotensin; Large Neuromedin N; Neuromedin N Preproprotein; NMN-125; NN; NT; NT/N; NTRH; NTS; NTS1; Proneuromedin N mRNA; Tail Peptide); Anti -Neurotensin; anti-NTS antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Neurotensin, NT. No significant sequence homology exist with other neuromedins.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, 0.05% sodium azide.

• Applicable Applications for anti-NTS antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:1000-1:5000 using ECL.; ELISA: 1:100,000 using 50-100ng control peptide/well.
• Immunogen: Synthetic peptide of Human NT, 13aa in the N-terminus. Species sequence homology: 100% mouse, rat, bovine, canine and 92% in G. pig.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-NTS antibody

Neurotensin (NT) is an endogenous tridecapeptide neurotransmitter (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg- pro-Tyr-Ile-Leu-OH) that was originally isolated from bovine hypothalamus. NT influences distinct central and peripheral physiological functions in mammals. Central administration of NT modulates dopaminergic transmission and triggers hypothermic and naloxone-insensitive analgesic responses, whereas peripheral effects include hypotension, decrease gastric acid release, potentiation of lipid digestion. NT causes contraction of smooth muscle. NT is widely distributed throughout the CNS. It has been localized to catecholamine-containing neurons. NT gene (human chromosome 12q21) produces both NT and neuromedin N (NN). In the rat, the NT precursor consists of a 169-aa polypeptide. The signal peptide (1-22 aa) is removed to produce a peptide that is further processed to produce NN (142-147 aa) and NT (150-162 aa). NT sequence is completely conserved in mouse, rat, human, canine, bovine etc. NT initiates its biological action by interacting with two distinct G-protein coupled receptors (NTR1 and NTR2). Recently, a third receptor NTR3 has been identified that is identical to gp95/sortilin and it is not coupled via the G-proteins. All three receptors bind NT through its C-terminal hexapeptide sequence (8 RRPYIL 13). Biologically active NT (NT8-13) has also been shown to interact with the extracellular domain 3 (between TM6-7) of NTR1.

Product Categories/Family for anti-NTS antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 5453816
• NCBI GeneID: 4922
• NCBI Accession #: NP_006174.1
• NCBI GenBank Nucleotide #: NM_006183.4
• UniProt Accession #: P30990
• Molecular Weight: 19,795 Da
• NCBI Official Full Name: neurotensin/neuromedin N preproprotein
• NCBI Official Synonym Full Names: neurotensin
• NCBI Official Symbol: NTS
• NCBI Official Synonym Symbols: NN; NT; NT/N; NTS1; NMN-125
• NCBI Protein Information: neurotensin/neuromedin N; pro-neurotensin/neuromedin
• UniProt Protein Name: Neurotensin/neuromedin N
• Protein Family: Neurotensin
• UniProt Gene Name: NTS
• UniProt Synonym Gene Names: NN; NmN; NT
• UniProt Entry Name: NEUT_HUMAN

NCBI Description

This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Jul 2008]

Uniprot Description

NTS: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. Belongs to the neurotensin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: transport vesicle; extracellular region

Molecular Function: neuropeptide hormone activity; protein binding

Biological Process: signal transduction; regulation of blood vessel size