Goat Neuroligin 1 Polyclonal Antibody | anti-NLGN1 antibody
Goat anti-Neuroligin 1 Antibody
Western Blot: Preliminary experiments gave an approx 150kDa band in Human Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 92. 0 kDa according to NP_055747.1. The 150kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Uniprot Description
NLGN1: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q26.31
Cellular Component: cell junction; cell surface; cytosol; dendrite; dendritic shaft; dendritic spine; external side of plasma membrane; extracellular space; filopodium tip; Golgi apparatus; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane; synapse
Molecular Function: cell adhesion molecule binding; neurexin binding; PDZ domain binding; protein dimerization activity; receptor activity
Biological Process: calcium-dependent cell-cell adhesion; cytoskeletal matrix organization at active zone; establishment of protein localization; heterophilic cell adhesion; nervous system development; neurite development; neurological control of breathing; neuron adhesion; positive regulation of filopodium formation; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein heterotetramerization; protein homooligomerization; protein targeting; regulation of neuron differentiation; rhythmic process; synaptic vesicle targeting; synaptogenesis
Research Articles on NLGN1
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Product Notes
The NLGN1 nlgn1 (Catalog #AAA420638) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Neuroligin 1 Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's Neuroligin 1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments gave an approx 150kDa band in Human Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 92. 0 kDa according to NP_055747.1. The 150kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the NLGN1 nlgn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: TAKQDDPKQQ. It is sometimes possible for the material contained within the vial of "Neuroligin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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