Rabbit anti-Human, Mouse NEK1 Polyclonal Antibody | anti-NEK1 antibody

NEK1 Antibody

Cat. Num. AAA9414100

• Gene Names: NEK1; SRPS2; SRTD6; SRPS2A; NY-REN-55
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: NEK1; Polyclonal Antibody; NEK1 Antibody; SRPS2; SRPS2A; NY-REN-55; anti-NEK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total NEK1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1286

• Applicable Applications for anti-NEK1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human NIMA-related kinase 1
• Target Name: NEK1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human lymphoma tissue using at dilution 1/25.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/25.)

Related Product Information for anti-NEK1 antibody

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-NEK1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 313661426
• NCBI GeneID: 4750
• NCBI Accession #: NP_001186326.1
• NCBI GenBank Nucleotide #: NM_001199397.1
• UniProt Accession #: Q96PY6; Q05DG5; Q14CB7; Q5H9T1; Q6PIB8; Q96SS2; Q9H6P7; Q9Y594; G5E9Z3
• Molecular Weight: 141,053 Da
• NCBI Official Full Name: serine/threonine-protein kinase Nek1 isoform 1
• NCBI Official Synonym Full Names: NIMA-related kinase 1
• NCBI Official Symbol: NEK1
• NCBI Official Synonym Symbols: SRPS2; SRTD6; SRPS2A; NY-REN-55
• NCBI Protein Information: serine/threonine-protein kinase Nek1
• UniProt Protein Name: Serine/threonine-protein kinase Nek1
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: NEK1
• UniProt Synonym Gene Names: KIAA1901; NimA-related protein kinase 1
• UniProt Entry Name: NEK1_HUMAN

NCBI Description

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

NEK1: a protein kinase related to the NIMA (never in mitosis, gene A) serine/threonine kinase of Aspergillus nidulans. Expressed at high levels during gametogenesis and neurons of the peripheral ganglia. Implicated in the control of meiosis. Mouse mutants lead to facial malformation, male sterility and polycystic kidney disease. Two alternatively spliced human isoforms have been reported.

Protein type: Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; NEK family

Chromosomal Location of Human Ortholog: 4q33

Cellular Component: centrosome; pericentriolar material; cytoplasm; nucleus

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; metal ion binding; ATP binding; protein kinase activity

Biological Process: mitosis; peptidyl-tyrosine phosphorylation; activation of MAPK activity; cell division; MAPKKK cascade; cilium biogenesis; response to ionizing radiation; response to DNA damage stimulus

Disease: Short-rib Thoracic Dysplasia 6 With Or Without Polydactyly