Rabbit anti-Human NEB Polyclonal Antibody | anti-NEB antibody

NEB Antibody

Cat. Num. AAA9403066

• Gene Names: NEB; NEM2; NEB177D
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: NEB; Polyclonal Antibody; NEB Antibody; NEM2; NEB177D; anti-NEB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total NEB protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.9 mg/ml (varies by lot)
• Sequence Length: 6669

• Applicable Applications for anti-NEB antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human nebulin
• Target Name: NEB
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/80.)

Related Product Information for anti-NEB antibody

This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy.

Product Categories/Family for anti-NEB antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 115527120
• NCBI GeneID: 4703
• NCBI Accession #: NP_004534.2
• NCBI GenBank Nucleotide #: NM_004543.4
• UniProt Accession #: P20929; Q15346; Q53QQ2; Q53TG8; F8WCL5; F8WCP0
• Molecular Weight: 772,927 Da
• NCBI Official Full Name: nebulin isoform 3
• NCBI Official Synonym Full Names: nebulin
• NCBI Official Symbol: NEB
• NCBI Official Synonym Symbols: NEM2; NEB177D
• NCBI Protein Information: nebulin
• UniProt Protein Name: Nebulin
• Protein Family: Nebulin
• UniProt Gene Name: NEB
• UniProt Entry Name: NEBU_HUMAN

NCBI Description

This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy. [provided by RefSeq, Sep 2009]

Uniprot Description

This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin.