Rabbit anti-Rat Nav1.5 Polyclonal Antibody | anti-Nav1.5 antibody

Anti-Nav1.5 Antibody

Cat. Num. AAA4159181

• Gene Names: SCN5A; HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5
• Reactivity: Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: Nav1.5; Polyclonal Antibody; Anti-Nav1.5 Antibody; anti-Nav1.5 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: Mouse-identical; human (17/19 residues identical).
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 113

• Applicable Applications for anti-Nav1.5 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: Rat heart membranes and human-Nav1.5 transfected HEK-293 cells (1:100-1:200); IHC: Rat heart paraffin sections.
• Immunogen: Peptide, DRLPKSDSEDGPRALNQLSC, corresponding to residues 493-511 of rH1 (accession number P15389).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-Nav1.5 antibody

SKM2, SCNSA Voltage-gated Na+ channels (Nav) are responsible for myocardial conduction and maintenance of the cardiac rhythm and are essential for the generation of action potentials and cell excitability.1 Dysfunction or disregulation of cardiac sodium channels can cause several disorders, including cardiac arrhythmias. The majority of Na+ channels in the mammalian heart are Tetrodotoxin (TTX)-insensitive Nav1.5.2 The putative structure of NaV1.5 consists of four homologous domain (I-IV), each containing six transmembrane segments (S1-S6). Mutations in the C-terminus of NaV1.5 were described in connection to Long QT syndrome and Brugada syndrome.1-2 Recent data have demonstrated selective expression of NaV1.5 in the mouse central nervous system and implicated a role for NaV1.5 in the physiology of the central nervous system.1

NCBI and Uniprot Product Information

• NCBI GI #: 18073691
• NCBI GeneID: 6331
• NCBI Official Full Name: Nav1.5, partial
• NCBI Official Synonym Full Names: sodium voltage-gated channel alpha subunit 5
• NCBI Official Symbol: SCN5A
• NCBI Official Synonym Symbols: HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5
• NCBI Protein Information: sodium channel protein type 5 subunit alpha

NCBI Description

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]