Sheep anti-Human Natriuretic Peptide, Pro, C-Type, aa1-19 Polyclonal Antibody | anti-NPPB antibody

Natriuretic Peptide, Pro, C-Type, aa1-19 (pro-CNP)

Cat. Num. AAA619836

• Gene Names: NPPB; BNP
• Reactivity: Human
• Applications: ELISA
• Purity: Serum; Serum
• Synonyms: Natriuretic Peptide; Pro; C-Type; aa1-19; Polyclonal Antibody; aa1-19 (pro-CNP); Anti -Natriuretic Peptide; anti-NPPB antibody

• Host: Sheep
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human pro-Natriuretic Peptide C (aa 1-19)
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute in ddH2O.

• Applicable Applications for anti-NPPB antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:1000
• Immunogen: Synthetic human pro-CNP (aa 1-19: KPGAPPKVPRTPPAEELAE)
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-NPPB antibody

Antibodies; Abs to Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 113836
• NCBI GeneID: 4879
• UniProt Accession #: P16860; Q6FGY0; Q9P2Q7; B0ZBE9
• Molecular Weight: 14,726 Da
• NCBI Official Full Name: Natriuretic peptides B
• NCBI Official Synonym Full Names: natriuretic peptide B
• NCBI Official Symbol: NPPB
• NCBI Official Synonym Symbols: BNP
• NCBI Protein Information: natriuretic peptides B; natriuretic protein; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B
• UniProt Protein Name: Natriuretic peptides B
• Protein Family: Natriuretic peptides
• UniProt Gene Name: NPPB
• UniProt Synonym Gene Names: BNP(1-32); BNP-32
• UniProt Entry Name: ANFB_HUMAN

NCBI Description

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008]

Uniprot Description

NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: extracellular space; protein complex; extracellular region

Molecular Function: diuretic hormone activity; hormone activity; receptor binding

Biological Process: cGMP biosynthetic process; negative regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of vasodilation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; negative regulation of cell growth; body fluid secretion; regulation of blood vessel size