Rabbit anti-Human NAT8B Polyclonal Antibody | anti-NAT8B antibody

NAT8B Rabbit pAb

Cat. Num. AAA8549014

• Gene Names: NAT8B; CML2; Hcml2; NAT8BP
• Reactivity: Human
• Applications: Immunofluorescence
• Purity: Affinity Purified
• Synonyms: NAT8B; Polyclonal Antibody; NAT8B Rabbit pAb; CML2; Hcml2; NAT8BP; anti-NAT8B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 227

• Applicable Applications for anti-NAT8B antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-1:200
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 75-165 of human NAT8B (NP_057431.2).
• Cellular Localization: Endoplasmic Reticulum, Membrane
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-NAT8B antibody

May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).

NCBI and Uniprot Product Information

• NCBI GI #: 117168283
• NCBI GeneID: 51471
• NCBI Accession #: NP_057431.2
• NCBI GenBank Nucleotide #: NP_057431.2
• UniProt Accession #: Q9UHF3
• Molecular Weight: 25kDa
• NCBI Official Full Name: putative N-acetyltransferase 8B
• NCBI Official Synonym Full Names: N-acetyltransferase 8B (putative, gene/pseudogene)
• NCBI Official Symbol: NAT8B
• NCBI Official Synonym Symbols: CML2; Hcml2; NAT8BP
• NCBI Protein Information: putative N-acetyltransferase 8B
• UniProt Protein Name: Putative N-acetyltransferase 8B
• Protein Family: Putative N-acetyltransferase
• UniProt Gene Name: NAT8B
• UniProt Synonym Gene Names: ATase1

NCBI Description

The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]

Uniprot Description

NAT8B: May play a role in regulation of gastrulation. Belongs to the camello family.

Protein type: Acetyltransferase; EC 2.3.1.-; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; integral component of membrane

Molecular Function: lysine N-acetyltransferase activity; N-acetyltransferase activity; protein binding

Biological Process: beta-amyloid metabolic process; cellular protein metabolic process; gastrulation with mouth forming second; negative regulation of apoptosis; peptidyl-lysine N6-acetylation