Rabbit anti-Human NAP1 Polyclonal Antibody | anti-AZI2 antibody

NAP1 Antibody

Cat. Num. AAA9205855

• Gene Names: AZI2; AZ2; NAP1; TILP
• Reactivity: Human
• Applications: Western Blot, ELISA, Immunocytochemistry, Immunohistochemistry
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: NAP1; Polyclonal Antibody; NAP1 Antibody; 5-azacytidine-induced protein 2; NF-kappa-B-activating kinase-associated protein 1; Nak-associated protein 1; TILP; AZI2; TBKBP2; anti-AZI2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
• Concentration: 1mg/ml (varies by lot)
• Sequence Positions: 1-60
• Sequence Length: 243

• Applicable Applications for anti-AZI2 antibody: Western Blot (WB), ELISA (EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC)-Paraffin
• Application Notes: WB~~ 1:1000
• Antigen Type: synthetic peptide
• Antigen Source: KLH conjugated synthetic peptide derived from human NAP1
• Preparation and Storage: Store at -20 degree C.Stable for 12 months from date of receipt

Western Blot (WB)

(Anti-NAP1 Antibody at 1:1000 dilution + HepG2 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilutionPredicted band size : 45 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-AZI2 antibody

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.

Product Categories/Family for anti-AZI2 antibody

Signal Transduction

References

Fujita F.,et al.Mol. Cell. Biol. 23:7780-7793(2003).
Inohara N.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

• NCBI GI #: 197313705
• NCBI GeneID: 64343
• NCBI Accession #: NP_001127904.1
• NCBI GenBank Nucleotide #: NM_001134432.1
• UniProt Accession #: Q9H6S1; Q86W99; Q9BQF1; A8K3M2; C9JB40; H7BXU6
• Molecular Weight: 44935
• NCBI Official Full Name: 5-azacytidine-induced protein 2 isoform b
• NCBI Official Synonym Full Names: 5-azacytidine induced 2
• NCBI Official Symbol: AZI2
• NCBI Official Synonym Symbols: AZ2; NAP1; TILP
• NCBI Protein Information: 5-azacytidine-induced protein 2
• UniProt Protein Name: 5-azacytidine-induced protein 2
• Protein Family: NAP1-binding protein
• UniProt Gene Name: AZI2
• UniProt Synonym Gene Names: NAP1; TBKBP2; Nak-associated protein 1
• UniProt Entry Name: AZI2_HUMAN

NCBI Description

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

Uniprot Description

AZI2: Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 3p24.1

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: tumor necrosis factor production; I-kappaB kinase/NF-kappaB cascade; T cell activation; interleukin-6 production; interferon-gamma production; mitotic cell cycle; interferon-alpha production