Western Blot (WB)
(NACC2 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the NACC2 antibody detected the NACC2 protein (arrow).)
Rabbit anti-Human NACC2 Polyclonal Antibody | anti-NACC2 antibody
NACC2 Antibody (C-term)
Gene Names
NACC2; RBB; BEND9; NAC-2; BTBD14; BTBD31; BTBD14A
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
NACC2; Polyclonal Antibody; NACC2 Antibody (C-term); Nucleus accumbens-associated protein 2; NAC-2; BTB/POZ domain-containing protein 14A; Repressor with BTB domain and BEN domain; BTBD14A; NAC2; RBB; anti-NACC2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This NACC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-502 amino acids from the C-terminal region of human NACC2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.3 (varies by lot)
Sequence Positions
473-502
Sequence Length
587
Applicable Applications for anti-NACC2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(NACC2 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the NACC2 antibody detected the NACC2 protein (arrow).)
Western Blot (WB)
(NACC2 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the NACC2 antibody detected the NACC2 protein (arrow).)
Related Product Information for anti-NACC2 antibody
BTBD14A (BTB/POZ domain-containing protein 14A), also known as BTBD14, is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD14A may play a role in transcription regulation.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
62837
NCBI Official Full Name
nucleus accumbens-associated protein 2
NCBI Official Synonym Full Names
NACC family member 2, BEN and BTB (POZ) domain containing
NCBI Official Symbol
NACC2
NCBI Official Synonym Symbols
RBB; BEND9; NAC-2; BTBD14; BTBD31; BTBD14A
NCBI Protein Information
nucleus accumbens-associated protein 2
UniProt Protein Name
Nucleus accumbens-associated protein 2
Protein Family
UniProt Gene Name
NACC2
UniProt Synonym Gene Names
BTBD14A; NAC2; RBB; NAC-2
UniProt Entry Name
NACC2_HUMAN
Uniprot Description
BTBD14A: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: nuclear body; nuclear chromatin; NuRD complex; nucleus
Molecular Function: protein binding; protein homodimerization activity; histone deacetylase binding; histone deacetylase activity
Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; positive regulation of cell proliferation; histone deacetylation; negative regulation of transcription, DNA-dependent; protein homooligomerization
Research Articles on NACC2
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Product Notes
The NACC2 nacc2 (Catalog #AAA9204777) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 473-502. The NACC2 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NACC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the NACC2 nacc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NACC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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