Testing Data
(Sample (30 ug of whole cell lysate) A: Hep G2 7.5% SDS PAGE Primary antibody diluted at 1: 1000)
Rabbit anti-Human Myotubularin related protein 2 Polyclonal Antibody | anti-MTMR2 antibody
Myotubularin related protein 2 antibody
Immunohistochemistry: 1:100-1:250
Testing Data
(Sample (30 ug of whole cell lysate) A: Hep G2 7.5% SDS PAGE Primary antibody diluted at 1: 1000)
Testing Data
(Sample (30 ug of whole cell lysate) A: Hep G2 7.5% SDS PAGE Primary antibody diluted at 1: 1000)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded CL1-0 xenograft, using Myotubularin related protein 2 antibody at 1: 100 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded CL1-0 xenograft, using Myotubularin related protein 2 antibody at 1: 100 dilution.)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
MTMR2: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Homooligomer and heterooligomer. Interacts with SBF1 and SBF2. interaction with SBF1 increases phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Protein type: Phosphatase, lipid; EC 3.1.3.64; Carbohydrate Metabolism - fructose and mannose; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.95; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine
Chromosomal Location of Human Ortholog: 11q22
Cellular Component: synaptic vesicle; early endosome membrane; axon; vacuolar membrane; cytoplasm; dendrite; dendritic spine; nucleus; cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding; protein homodimerization activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: myelin formation; negative regulation of myelination; phospholipid metabolic process; negative regulation of endocytosis; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; neuron development; phosphoinositide dephosphorylation; protein amino acid dephosphorylation; protein tetramerization; negative regulation of receptor internalization
Disease: Charcot-marie-tooth Disease, Type 4b1
Research Articles on MTMR2
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Product Notes
The MTMR2 mtmr2 (Catalog #AAA9412016) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Myotubularin related protein 2 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Myotubularin related protein 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:250. Researchers should empirically determine the suitability of the MTMR2 mtmr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Myotubularin related protein 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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