Testing Data
(MEK293 overexpressing MTM1 and probed with MBS630467 (mock transfection in first lane))
Goat anti-Human Myotubular Myopathy 1 Polyclonal Antibody | anti-MTMR1 antibody
Myotubular Myopathy 1 (MTM1, CNM, MTMX, Myotubularin, XLMTM)
Purified by peptide affinity chromatography.
Purified by peptide affinity chromatography.
Dilution: Peptide ELISA Titer: 1:16,000
Western Blot: ~70kD band observed in lysates of Human Muscle and of cell line HepG2 (calculated MW of 69.9kD according to NP_000243.1). In transfected HEK293 transiently expressing MTM1 a band of approx. 65kD is observed. This band is not observed in the non-transfected
Testing Data
(MEK293 overexpressing MTM1 and probed with MBS630467 (mock transfection in first lane))
Testing Data
(MEK293 overexpressing MTM1 and probed with MBS630467 (mock transfection in first lane))
Chemiluminescence
(MBS630467 (0.3µg/ml) staining of HepG2 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Chemiluminescence
(MBS630467 (0.3µg/ml) staining of HepG2 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the myotubularin related family of proteins. Members of this family contain the consensus sequence for the active site of protein tyrosine phosphatases. Alternatively spliced variants have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
MTMR1: Lipid phosphatase that acts on phosphatidylinositol 3- phosphate and phosphatidylinositol (3,5)-bisphosphate. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.64; Protein phosphatase, tyrosine (non-receptor); Cofactor and Vitamin Metabolism - thiamine; Carbohydrate Metabolism - fructose and mannose; Phosphatase, lipid; Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - riboflavin
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity
Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation
Research Articles on MTMR1
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Product Notes
The MTMR1 mtmr1 (Catalog #AAA630467) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Myotubular Myopathy 1 (MTM1, CNM, MTMX, Myotubularin, XLMTM) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Myotubular Myopathy 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Peptide ELISA Titer: 1:16,000 Western Blot: ~70kD band observed in lysates of Human Muscle and of cell line HepG2 (calculated MW of 69.9kD according to NP_000243.1). In transfected HEK293 transiently expressing MTM1 a band of approx. 65kD is observed. This band is not observed in the non-transfected. Researchers should empirically determine the suitability of the MTMR1 mtmr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Myotubular Myopathy 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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