Rabbit MYL3 Polyclonal Antibody | anti-MYL3 antibody

MYL3 Rabbit Polyclonal

Cat. Num. AAA7601720

• Gene Names: MYL3; CMH8; VLC1; VLCl; MLC1V; MLC1SB; MLC-lV/sb
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MYL3; Polyclonal Antibody; MYL3 Rabbit Polyclonal; anti-MYL3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 195

• Applicable Applications for anti-MYL3 antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: Myosin, light chain 3, alkali; ventricular, skeletal, slow
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS7601720 (MYL3 Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse skeletal muscle were subjected to SDS PAGE followed by western blot with MBS7601720 (MYL3 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 4557777
• NCBI GeneID: 4634
• NCBI Accession #: NP_000249.1
• NCBI GenBank Nucleotide #: NM_000258.2
• Molecular Weight: 21,932 Da
• NCBI Official Full Name: myosin light chain 3
• NCBI Official Synonym Full Names: myosin light chain 3
• NCBI Official Symbol: MYL3
• NCBI Official Synonym Symbols: CMH8; VLC1; VLCl; MLC1V; MLC1SB; MLC-lV/sb
• NCBI Protein Information: myosin light chain 3
• UniProt Protein Name: Myosin light chain 3
• Protein Family: Myosin
• UniProt Gene Name: MYL3
• UniProt Synonym Gene Names: MLC-lV/sb
• UniProt Entry Name: MYL3_HUMAN

NCBI Description

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Uniprot Description

MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.3-p21.2

Cellular Component: A band; cytosol; I band; muscle myosin complex; sarcomere

Molecular Function: actin monomer binding; calcium ion binding; motor activity; myosin II heavy chain binding; structural constituent of muscle

Biological Process: cardiac muscle contraction; metabolic process; muscle filament sliding; positive regulation of ATPase activity; regulation of striated muscle contraction; regulation of the force of heart contraction; skeletal muscle development; ventricular cardiac muscle morphogenesis

Disease: Cardiomyopathy, Familial Hypertrophic, 8