Western Blot (WB)
(mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS7601701 (MYF6 antibody) at dilution of 1:500)
Rabbit MYF6 Polyclonal Antibody | anti-MYF6 antibody
MYF6 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS7601701 (MYF6 antibody) at dilution of 1:500)
Western Blot (WB)
(mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS7601701 (MYF6 antibody) at dilution of 1:500)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]
Uniprot Description
Myf-6: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Defects in MYF6 may be a cause of centronuclear myopathy type 3 (CNM3). A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q21
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity
Biological Process: muscle cell fate commitment; negative regulation of transcription, DNA-dependent; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of skeletal muscle fiber development; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; skeletal muscle development; skeletal muscle regeneration; somitogenesis; transcription from RNA polymerase II promoter
Disease: Myopathy, Centronuclear, 3
Research Articles on MYF6
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Product Notes
The MYF6 myf6 (Catalog #AAA7601701) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MYF6 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MYF6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the MYF6 myf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MYF6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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