Rabbit anti-Rat Myeloid Differentiation Factor 88 Polyclonal Antibody | anti-MyD88 antibody

Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88)

Cat. Num. AAA2026383

• Reactivity: Rat
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA
• Purity: Affinity Chromatography
• Synonyms: Myeloid Differentiation Factor 88; Polyclonal Antibody; Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88); anti-MyD88 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: The antibody is a rabbit polyclonal antibody raised against MyD88. It has beenselected for its ability to recognize MyD88 in immunohistochemical staining andwestern blotting.
• Purity/Purification: Affinity Chromatography
• Form/Format: Liquid
• Concentration: 500ug/mL (varies by lot)
• Sequence Length: 285

• Applicable Applications for anti-MyD88 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
• Application Notes: Western blotting: 0.5-2ug/mL;1:300-1300; Immunohistochemistry: 5-20ug/mL;1:30-130; Immunocytochemistry: 5-20ug/mL;1:30-130; Optimal working dilutions must be determined by end user.
• Fragment: MyD88 (Met1~Pro296)
• Organism Species: Rattus norvegicus (Rat)
• Cross Reactivity: Rat
• Conjugate: No Conjugate
• Immunogen: Recombinant MyD88 (Met1~Pro296) expressed in E Coli.
• Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2058156
• Preparation and Storage: Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Western Blot: Sample: Recombinant protein.)

Immunohistochemistry (IHC)

(DABstainingonIHC-P.Samples:RatTissue))

NCBI and Uniprot Product Information

• NCBI GI #: 37693503
• NCBI GeneID: 301059
• NCBI Accession #: NP_937763.1
• NCBI GenBank Nucleotide #: NM_198130.1
• UniProt Accession #: Q6Y1S1; Q4QRC0
• Molecular Weight: 33,856 Da
• NCBI Official Full Name: myeloid differentiation primary response protein MyD88
• NCBI Official Synonym Full Names: myeloid differentiation primary response 88
• NCBI Official Symbol: Myd88
• NCBI Protein Information: myeloid differentiation primary response protein MyD88
• UniProt Protein Name: Myeloid differentiation primary response protein MyD88
• Protein Family: Myeloid differentiation primary response protein
• UniProt Gene Name: Myd88

NCBI Description

an adaptor protein which binds toll-like receptors and links them to other downstream signalling molecules [RGD, Feb 2006]

Uniprot Description

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine ().