Rabbit MYBPC2 Polyclonal Antibody | anti-MYBPC2 antibody

MYBPC2 Polyclonal Antibody

Cat. Num. AAA3006444

• Gene Names: MYBPC2; MYBPC; MYBPCF; fsMyBP-C
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: MYBPC2; Polyclonal Antibody; MYBPC2 Polyclonal Antibody; Myosin-binding protein C; fast-type; Fast MyBP-C; C-protein; skeletal muscle fast isoform; MYBPCF; anti-MYBPC2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MYBPC2 polyclonal antibody detects endogenous levels of MYBPC2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1141

• Applicable Applications for anti-MYBPC2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human MYBPC2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of MYBPC2 polyclonal antibody at 1:500 dilutionLane1:Hela whole cell lysateLane2:NIH-3T3 whole cell lysateLane3:H9C2 whole cell lysate)

Related Product Information for anti-MYBPC2 antibody

MYBPC2, also known as MYBPCF or MYBPC, is a 1, 142 amino acid protein that contains 3 fibronectin type-III domains and 7 Ig-like C 2-type domains. Existing as a member of the immunoglobulin superfamily, MYBPC2 functions as a thick filament-associated protein that localizes to striated muscle bands in vertebrae and is thought to modify the activity of select ATPases. Additionally, MYBPC2 may play a role in the modulation of muscle contraction and in the overall structural integrity of the cell. The gene encoding MYBPC2 maps to human chromosome 19, which is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs).

NCBI and Uniprot Product Information

• NCBI GI #: 119592272
• NCBI GeneID: 4606
• UniProt Accession #: Q14324
• Molecular Weight: ~ 128kDa
• NCBI Official Full Name: myosin binding protein C, fast type, isoform CRA_b
• NCBI Official Synonym Full Names: myosin binding protein C2
• NCBI Official Symbol: MYBPC2
• NCBI Official Synonym Symbols: MYBPC; MYBPCF; fsMyBP-C
• NCBI Protein Information: myosin-binding protein C, fast-type
• UniProt Protein Name: Myosin-binding protein C, fast-type
• Protein Family: Myosin-binding protein
• UniProt Gene Name: MYBPC2
• UniProt Synonym Gene Names: MYBPCF; Fast MyBP-C
• UniProt Entry Name: MYPC2_HUMAN

NCBI Description

This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively. [provided by RefSeq, Jul 2012]

Uniprot Description

MYBPC2: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family.

Protein type: Myosin-binding

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytosol

Molecular Function: protein binding; structural constituent of muscle; actin binding

Biological Process: cell adhesion; muscle filament sliding