Rabbit anti-Human MX2 Polyclonal Antibody | anti-MX2 antibody

MX2 Antibody

Cat. Num. AAA9414619

• Gene Names: MX2; MXB
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: MX2; Polyclonal Antibody; MX2 Antibody; Interferon-induced GTP-binding protein Mx2; Interferon-regulated resistance GTP-binding protein MxB; MXB; myxovirus (influenza virus) resistance 2 (mouse); anti-MX2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total MX2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 715

• Applicable Applications for anti-MX2 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from Internal of human MX2.
• Target Name: MX2
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from 293 cells, using MX2 antibody.)

Related Product Information for anti-MX2 antibody

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.Aebi M., Mol. Cell. Biol. 9:5062-5072(1989).Hattori M., Nature 405:311-319(2000).Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

Product Categories/Family for anti-MX2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 11342664
• NCBI GeneID: 4600
• NCBI Accession #: NP_002454.1
• NCBI GenBank Nucleotide #: NM_002463.1
• UniProt Accession #: P20592; B7Z5D3; D3DSI7
• Molecular Weight: 22,105 Da
• NCBI Official Full Name: interferon-induced GTP-binding protein Mx2
• NCBI Official Synonym Full Names: MX dynamin-like GTPase 2
• NCBI Official Symbol: MX2
• NCBI Official Synonym Symbols: MXB
• NCBI Protein Information: interferon-induced GTP-binding protein Mx2
• UniProt Protein Name: Interferon-induced GTP-binding protein Mx2
• Protein Family: Interferon-induced GTP-binding protein
• UniProt Gene Name: MX2
• UniProt Entry Name: MX2_HUMAN

NCBI Description

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

Uniprot Description

MX2: has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; nuclear pore; cytosol; nucleus

Molecular Function: GTPase activity; GTP binding

Biological Process: protein transport; mRNA transport; regulation of cell cycle; metabolic process; response to virus; regulation of nucleocytoplasmic transport; cytokine and chemokine mediated signaling pathway; defense response; defense response to virus