Rabbit MTUS1 Polyclonal Antibody | anti-MTUS1 antibody

MTUS1 Polyclonal Antibody

Cat. Num. AAA9127884

• Gene Names: MTUS1; ATBP; ATIP; ICIS; MP44; MTSG1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: MTUS1; Polyclonal Antibody; MTUS1 Polyclonal Antibody; anti-MTUS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 415

• Applicable Applications for anti-MTUS1 antibody: Western Blot (WB)
• Application Notes: WB 1:500 - 1:2000
• Immunogen: Recombinant Protein
• Immunogen: Recombinant protein of human MTUS1
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.; Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using MTUS1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.)

Related Product Information for anti-MTUS1 antibody

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 50348611
• NCBI GeneID: 57509
• NCBI Accession #: NP_001001924.1
• NCBI GenBank Nucleotide #: NM_001001924.2
• UniProt Accession #: Q9ULD2; Q63HJ6; Q659F4; Q6PK49; Q6URW7; Q8N4M6; A8K135; B2RBJ6; B3KWJ9; B4DH03; B9EGA1; D3DSP8
• Molecular Weight: 141kDa
• NCBI Official Full Name: microtubule-associated tumor suppressor 1 isoform 1
• NCBI Official Synonym Full Names: microtubule associated tumor suppressor 1
• NCBI Official Symbol: MTUS1
• NCBI Official Synonym Symbols: ATBP; ATIP; ICIS; MP44; MTSG1
• NCBI Protein Information: microtubule-associated tumor suppressor 1
• UniProt Protein Name: Microtubule-associated tumor suppressor 1
• Protein Family: Microtubule-associated tumor suppressor
• UniProt Gene Name: MTUS1
• UniProt Synonym Gene Names: ATBP; ATIP; GK1; KIAA1288; MTSG1
• UniProt Entry Name: MTUS1_HUMAN

NCBI Description

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]

Uniprot Description

MTUS1: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. Defects in MTUS1 may be a cause of hepatocellular carcinoma (HCC). Belongs to the MTUS1 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Tumor suppressor

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: Golgi apparatus; extracellular space; microtubule; mitochondrion; plasma membrane; microtubule organizing center; spindle; nucleus