Rabbit anti-Human MTRR Polyclonal Antibody | anti-MTRR antibody

MTRR Polyclonal Antibody

Cat. Num. AAA2555427

• Gene Names: MTRR; MSR; cblE
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: MTRR; Polyclonal Antibody; MTRR Polyclonal Antibody; [methionine synthase] cobalamin methyltransferase (cob(II)alamin reducing); 5 methyltetrahydrofolate homocysteine methyltransferase reductase; cblE; Methionine synthase reductase; mitochondrial; MGC129643; MSR; anti-MTRR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 698

• Applicable Applications for anti-MTRR antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human MTRR
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using MTRR antibody.)

Related Product Information for anti-MTRR antibody

This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 169790958
• NCBI GeneID: 4552
• NCBI Accession #: NP_002445.2
• NCBI GenBank Nucleotide #: NM_002454.2
• UniProt Accession #: Q9UBK8; O60471; Q32MA9; Q7Z4M8
• Molecular Weight: Calculated: 6kDa; 77kDa; 80kDa; Observed: 80kDa
• NCBI Official Full Name: methionine synthase reductase
• NCBI Official Synonym Full Names: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
• NCBI Official Symbol: MTRR
• NCBI Official Synonym Symbols: MSR; cblE
• NCBI Protein Information: methionine synthase reductase
• UniProt Protein Name: Methionine synthase reductase
• Protein Family: Methionine synthase reductase
• UniProt Gene Name: MTRR
• UniProt Synonym Gene Names: MSR

NCBI Description

This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Description

Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects.