Rabbit anti-Human MTDH Polyclonal Antibody | anti-MTDH antibody

MTDH (Protein LYRIC, 3D3/LYRIC, Astrocyte Elevated gene-1 Protein, AEG-1, Lysine-rich CEACAM1 Co-isolated Protein, Metadherin, Metastasis Adhesion Protein, AEG1, LYRIC)

Cat. Num. AAA641927

• Gene Names: MTDH; 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation
• Purity: Serum; Serum
• Synonyms: MTDH; Polyclonal Antibody; MTDH (Protein LYRIC; 3D3/LYRIC; Astrocyte Elevated gene-1 Protein; AEG-1; Lysine-rich CEACAM1 Co-isolated Protein; Metadherin; Metastasis Adhesion Protein; AEG1; LYRIC); Anti -MTDH (Protein LYRIC; anti-MTDH antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MTDH.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid.
• Sequence: MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGSRKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKAEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET

• Applicable Applications for anti-MTDH antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Western Blot and Immunoprecipitation.
• Immunogen: Full length human MTDH, aa1-582 (NP_848927.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of MTDH expression in transfected 293T cell line using MBS641927. Lane 1: MTDH transfected lysate (63.8kD). Lane 2: Non-transfected lysate.)

Immunoprecipitation (IP)

(Immunoprecipitation of MTDH transfected lysate using MBS641927 and Protein A Magnetic Bead and immunoblotted with MTDH mouse polyclonal antibody.)

Related Product Information for anti-MTDH antibody

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Product Categories/Family for anti-MTDH antibody

Antibodies; Abs to Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 33872575
• NCBI GeneID: 92140
• UniProt Accession #: Q86UE4; Q05DH2; Q52QU9; Q6PK07; Q8TCX3
• Molecular Weight: 63,837 Da
• NCBI Official Full Name: MTDH protein, partial
• NCBI Official Synonym Full Names: metadherin
• NCBI Official Symbol: MTDH
• NCBI Official Synonym Symbols: 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
• NCBI Protein Information: protein LYRIC; 3D3/LYRIC; metastasis adhesion protein; astrocyte elevated gene-1 protein; lysine-rich CEACAM1 co-isolated protein
• UniProt Protein Name: Protein LYRIC
• Protein Family: Protein LYRIC
• UniProt Gene Name: MTDH
• UniProt Synonym Gene Names: AEG1; LYRIC; AEG-1
• UniProt Entry Name: LYRIC_HUMAN

Uniprot Description

Lyric: a protein of unknown function.

Protein type: Cell adhesion; Nucleolus; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nuclear body; intercellular canaliculus; endoplasmic reticulum membrane; nuclear membrane; tight junction; perinuclear region of cytoplasm; endoplasmic reticulum; apical plasma membrane; cytoplasm; nucleolus; integral to membrane; nucleus

Molecular Function: NF-kappaB binding; protein binding; double-stranded RNA binding; transcription coactivator activity

Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; activation of NF-kappaB transcription factor; negative regulation of apoptosis