Western Blot (WB)
(Staining (0. 03ug/ml) of Human Placenta lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Goat MTA1 Polyclonal Antibody | anti-MTA1 antibody
Goat anti-MTA1 Antibody
Western Blot: Approx 75kDa band observed in Human Placenta lysates (calculated MW of 80.8kDa according to NP_004680.1). Recommended concentration: 0. 03-0.1ug/ml.
Western Blot (WB)
(Staining (0. 03ug/ml) of Human Placenta lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Western Blot (WB)
(Staining (0. 03ug/ml) of Human Placenta lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Uniprot Description
MTA1: metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 14q32.3
Cellular Component: cytoplasm; intracellular membrane-bound organelle; microtubule; nuclear envelope; nucleoplasm; nucleus
Molecular Function: chromatin binding; histone deacetylase activity; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding
Biological Process: circadian regulation of gene expression; double-strand break repair; entrainment of circadian clock by photoperiod; histone deacetylation; locomotor rhythm; proteasomal ubiquitin-dependent protein catabolic process; protein sumoylation; regulation of gene expression, epigenetic; regulation of inflammatory response; regulation of transcription, DNA-dependent; response to ionizing radiation; response to lipopolysaccharide; signal transduction; transcription, DNA-dependent
Research Articles on MTA1
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Product Notes
The MTA1 mta1 (Catalog #AAA421190) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-MTA1 Antibody reacts with Tested: Human; Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's MTA1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 75kDa band observed in Human Placenta lysates (calculated MW of 80.8kDa according to NP_004680.1). Recommended concentration: 0. 03-0.1ug/ml. Researchers should empirically determine the suitability of the MTA1 mta1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: PGDVFYMPKE. It is sometimes possible for the material contained within the vial of "MTA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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