Rabbit anti-Human MT3 Polyclonal Antibody | anti-MT3 antibody

MT3 Antibody

Cat. Num. AAA9405922

• Gene Names: MT3; GIF; GIFB; GRIF; ZnMT3
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: MT3; Polyclonal Antibody; MT3 Antibody; GIF; GIFB; GRIF; ZnMT3; anti-MT3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total MT3 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.1 mg/ml (varies by lot)
• Sequence Length: 68

• Applicable Applications for anti-MT3 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Full length fusion protein
• Target Name: MT3
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/50.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/50.)

Related Product Information for anti-MT3 antibody

Metallothionein (MT) is a sulfhydryl- and cysteine-rich protein found in micro-organisms, plants and all invertebrate and vertebrate animals. Metallothioneins are a group of ubiquitous low-molecular-weight proteins that have functional roles in cell growth, repair and differentiation. Metallothionein are implicated primarily in metal ion detoxification as they are essential for the protection of cells against the toxicity of cadmium, mercury and copper. Metallothioneins are known to be broadly expressed in heart, liver, kidney, breast and testis tissue. Metallothionein 3, also known as MT-3 or GIFB (growth inhibitory factor), is a 68 amino acid protein that belongs to the type 1 family and Metallothionein superfamily. While highly expressed in astrocytes of the normal human brain, Metallothionein 3 expression is reduced in the brains of patients with Alzheimer disease.

Product Categories/Family for anti-MT3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 5174762
• NCBI GeneID: 4504
• NCBI Accession #: NP_005945.1
• NCBI GenBank Nucleotide #: NM_005954.2
• UniProt Accession #: P25713; Q2V574
• Molecular Weight: 6,927 Da
• NCBI Official Full Name: metallothionein-3
• NCBI Official Synonym Full Names: metallothionein 3
• NCBI Official Symbol: MT3
• NCBI Official Synonym Symbols: GIF; GIFB; GRIF; ZnMT3
• NCBI Protein Information: metallothionein-3
• UniProt Protein Name: Metallothionein-3
• Protein Family: Metallothionein
• UniProt Gene Name: MT3
• UniProt Synonym Gene Names: MT-3; GIF; MT-III
• UniProt Entry Name: MT3_HUMAN

Uniprot Description

MT3: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro. Belongs to the metallothionein superfamily. Type 1 family.

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: synaptic vesicle; perinuclear region of cytoplasm; cytoplasm; inclusion body; intracellular

Molecular Function: antioxidant activity; protein binding; copper ion binding; zinc ion binding; caspase inhibitor activity; drug binding; cadmium ion binding; protein kinase activator activity

Biological Process: positive regulation of catalytic activity; negative regulation of autophagy; removal of superoxide radicals; positive regulation of transcription, DNA-dependent; negative regulation of axon extension; negative regulation of caspase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; zinc ion homeostasis; cadmium ion homeostasis; cellular lipid catabolic process; histone modification; protein kinase B signaling cascade; negative regulation of neuron apoptosis; cholesterol catabolic process; regulation of response to food; protein stabilization; activation of protein kinase B; cellular zinc ion homeostasis; zinc ion transport; regulation of protein amino acid glycosylation; leptin-mediated signaling pathway; astrocyte development; cell proliferation; cellular metal ion homeostasis; protein import into nucleus, translocation; negative regulation of oxidoreductase activity; response to hypoxia; energy reserve metabolic process; negative regulation of cell growth; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis