Rabbit MST1R / RON Polyclonal Antibody | anti-MST1R antibody

Rabbit Polyclonal to Human MST1R / RON

Cat. Num. AAA240876

• Gene Names: MST1R; RON; PTK8; CD136; CDw136
• Reactivity: Bat, Gorilla, Human, Monkey; Predicted Reactivity: Gibbon, Bovine, Dog (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: MST1R / RON; Polyclonal Antibody; Rabbit Polyclonal to Human MST1R / RON; Anti-MST1R / RON Antibody (Internal) IHC-plus; MST1R; C-met-related tyrosine kinase; CD136; CDw136; CD136 antigen; Friend virus susceptibility 2; Fv2; MSP receptor; p185-Ron; PTK8 protein tyrosine kinase 8; RON; Soluble RON variant 3; Soluble RON variant 1; MST1R variant RON30; Oncogene RON; Human MST1R; anti-MST1R antibody

• Host: Rabbit
• Reactivity: Bat, Gorilla, Human, Monkey; Predicted Reactivity: Gibbon, Bovine, Dog (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human MST1R / RON. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1400

• Applicable Applications for anti-MST1R antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (2.4 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from internal region of human MST1R / RON. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Bat, Panda (100%); Gibbon, Dog, Bovine (94%); Hamster, Elephant (89%); Marmoset, Horse (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: MST1R / RON antibody was raised against synthetic 18 amino acid peptide from internal region of human MST1R / RON. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Bat, Panda (100%); Gibbon, Dog, Bovine (94%); Hamster, Elephant (89%); Marmoset, Horse (83%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-MST1R / RON antibody IHC of human colon, surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-MST1R antibody

MST1R/Ron, a HGF Receptor/MET -type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain.

Product Categories/Family for anti-MST1R antibody

Family: Protein Kinase; Subfamily: HGF Receptor/MET

NCBI and Uniprot Product Information

• NCBI GI #: 153946393
• NCBI GeneID: 4486
• NCBI Accession #: NP_002438.2
• NCBI GenBank Nucleotide #: NM_002447.2
• UniProt Accession #: Q04912; B5A944; B5A945; B5A946; B5A947
• Molecular Weight: 69,265 Da
• NCBI Official Full Name: macrophage-stimulating protein receptor isoform 1 preproprotein
• NCBI Official Synonym Full Names: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
• NCBI Official Symbol: MST1R
• NCBI Official Synonym Symbols: RON; PTK8; CD136; CDw136
• NCBI Protein Information: macrophage-stimulating protein receptor; p185-Ron; MSP receptor; RON variant 21; RON variant E2E3; MST1R variant RON30; MST1R variant RON62; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4; c-met-related tyrosine kinase; PTK8 protein tyrosine kinase 8
• UniProt Protein Name: Macrophage-stimulating protein receptor
• Protein Family: Macrophage-stimulating protein receptor
• UniProt Gene Name: MST1R
• UniProt Synonym Gene Names: PTK8; RON; MSP receptor
• UniProt Entry Name: RON_HUMAN

NCBI Description

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]

Uniprot Description

Ron: a receptor tyrosine kinase of the Met family. Receptor for macrophage stimulating protein. Can be desensitized by c-Cbl and its binding partner Grb2. Overexpression of wild-type RON causes the formation of lung tumors. Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.1; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Met family

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cell surface; integral to plasma membrane; stress fiber

Molecular Function: macrophage colony stimulating factor receptor activity; protein binding; enzyme binding; ATP binding

Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; peptidyl-tyrosine phosphorylation; multicellular organismal development; single fertilization; response to virus; positive regulation of cell proliferation; innate immune response; defense response; signal transduction; cell motility; transmembrane receptor protein tyrosine kinase signaling pathway