Rabbit anti-Human, Mouse MRC2 Polyclonal Antibody | anti-MRC2 antibody

MRC2 Rabbit pAb

Cat. Num. AAA8547660

• Gene Names: MRC2; CD280; UPARAP; CLEC13E; ENDO180
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: MRC2; Polyclonal Antibody; MRC2 Rabbit pAb; CD280; UPARAP; CLEC13E; ENDO180; anti-MRC2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 1479

• Applicable Applications for anti-MRC2 antibody: Western Blot (WB)
• Application Notes: WB: 1:200-1:500
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 120-300 of human MRC2 (NP_006030.2).
• Cellular Localization: Membrane
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-MRC2 antibody

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

NCBI and Uniprot Product Information

• NCBI GI #: 110624774
• NCBI GeneID: 9902
• NCBI Accession #: NP_006030.2
• NCBI GenBank Nucleotide #: NP_006030.2
• UniProt Accession #: Q9UBG0
• Molecular Weight: 190kDa
• NCBI Official Full Name: C-type mannose receptor 2
• NCBI Official Synonym Full Names: mannose receptor C type 2
• NCBI Official Symbol: MRC2
• NCBI Official Synonym Symbols: CD280; UPARAP; CLEC13E; ENDO180
• NCBI Protein Information: C-type mannose receptor 2
• UniProt Protein Name: C-type mannose receptor 2
• Protein Family: C-type mannose receptor
• UniProt Gene Name: MRC2
• UniProt Synonym Gene Names: CLEC13E; ENDO180; KIAA0709; UPARAP; UPAR-associated protein
• UniProt Entry Name: MRC2_HUMAN

NCBI Description

This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]

Uniprot Description

MRC2: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: focal adhesion; membrane; integral to membrane

Molecular Function: collagen binding; protein binding; carbohydrate binding

Biological Process: osteoblast differentiation; collagen catabolic process; endocytosis