Rabbit MR1 Polyclonal Antibody | anti-MR1 antibody

Anti-MR1 Antibody

Cat. Num. AAA1751261

• Gene Names: MR1; HLALS
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Flow Cytometry, Functional Assay, ELISA
• Purity: Immunogen Affinity Purified
• Synonyms: MR1; Polyclonal Antibody; Anti-MR1 Antibody; Major histocompatibility complex class I-related gene protein; MHC class I-related gene protein; Class I histocompatibility antigen-like protein; anti-MR1 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized
• Sequence Length: 296

• Applicable Applications for anti-MR1 antibody: Western Blot (WB), Immunohistochemistry (IHC) Frozen, Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), Direct ELISA (EIA)
• Application Notes: WB: Concentration: 0.1-0.5ug/ml; FC: Concentration: 1-3ug/1x10⁶cells; EIA:0.1-0.5ug/ml; ; Tested Species: In-house tested species with positive results.; ; Other applications have not been tested. Optimal dilutions should be determined by end users.
• Immunogen: E Coli-derived human MR1 recombinant protein (Position: R23-D269).
• Species: Reacts with: Human , Mouse, Rat.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500mug/ml.
• Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Preparation and Storage: Store at -20 degree C for one year. After reconstitution, store at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.; Avoid repeated freezing and thawing.

Related Product Information for anti-MR1 antibody

Description: Rabbit IgG polyclonal antibody for MR1 detection. Tested with WB, IHC-F, ICC, FCM, Direct ELISA in Human; Mouse; Rat.
Background: Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1 gene. MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome.

References

1. "Entrez Gene: MR1 major histocompatibility complex, class I-related". 2. Hashimoto K, Hirai M, Kurosawa Y (Aug 1995). "A gene outside the human MHC related to classical HLA class I genes". Science. 269 (5224): 693-5. 3. Yamaguchi H, Kurosawa Y, Hashimoto K (Nov 1998). "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog". Biochem Biophys Res Commun. 250 (3): 558-64.

NCBI and Uniprot Product Information

• NCBI GI #: 303324539
• NCBI GeneID: 3140
• NCBI Accession #: NP_001181928.1
• NCBI GenBank Nucleotide #: NM_001194999.1
• UniProt Accession #: Q95460; O97985; O97986; Q53GM1; Q95HB8; Q9MY23; Q9NPL2; Q9TQB3; Q9TQB9; Q9TQK3; A8K2V9; B4E3B1
• NCBI Official Full Name: major histocompatibility complex class I-related gene protein isoform 2
• NCBI Official Synonym Full Names: major histocompatibility complex, class I-related
• NCBI Official Symbol: MR1
• NCBI Official Synonym Symbols: HLALS
• NCBI Protein Information: major histocompatibility complex class I-related gene protein
• UniProt Protein Name: Major histocompatibility complex class I-related gene protein
• Protein Family: Major histocompatibility complex class I-related gene protein
• UniProt Gene Name: MR1
• UniProt Synonym Gene Names: MHC class I-related gene protein

NCBI Description

MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]

Uniprot Description

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.