Rabbit MORF4L2 Polyclonal Antibody | anti-MORF4L2 antibody

MORF4L2 Polyclonal Antibody

Cat. Num. AAA3008784

• Gene Names: MORF4L2; MRGX; MORFL2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: MORF4L2; Polyclonal Antibody; MORF4L2 Polyclonal Antibody; MRGX; MORFL2; anti-MORF4L2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MORF4L2 polyclonal antibody detects endogenous levels of MORF4L2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 288

• Applicable Applications for anti-MORF4L2 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:50-1:200; IF: 1:50-1:100
• Immunogen: Recombinant protein of human MORF4L2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunofluorescence (IF)

(Immunofluorescence analysis of A549 cell using MORF4L2 antibody.)

Related Product Information for anti-MORF4L2 antibody

The members of the mortality factor family include mortality factor 4 (MORF4), mortality factor 4 like 1 (MORF4L1), also known as MORF4-related gene 15 (MRG15), and mortality factor 4 like 2 (MORF4L2), also known as MORF-4 related gene X (MRGX). The human MORF4 gene maps to chromosome 4q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. The genes encoding MORF4L1 and MORF4L2 map to chromosomes 15q25.1 and Xq22.2, respectively. MORF4, MORF4L1 and MORF4L2 each contain a C-terminal leucine zipper. An association between MORF4L1, Rb (retinoblastoma tumor suppressor) and PAM14 (protein associated with MORF4L1) suggests a role for MORF4L1 in transcription regulation. MORF4L1 also associates with the histone acetyl transferase MOF.

NCBI and Uniprot Product Information

• NCBI GI #: 215490021
• NCBI GeneID: 9643
• NCBI Accession #: NP_001135890.1
• NCBI GenBank Nucleotide #: NP_001135890.1
• UniProt Accession #: Q15014
• Molecular Weight: ~ 32kDa
• NCBI Official Full Name: mortality factor 4-like protein 2
• NCBI Official Synonym Full Names: mortality factor 4 like 2
• NCBI Official Symbol: MORF4L2
• NCBI Official Synonym Symbols: MRGX; MORFL2
• NCBI Protein Information: mortality factor 4-like protein 2
• UniProt Protein Name: Mortality factor 4-like protein 2
• Protein Family: Mortality factor 4-like protein
• UniProt Gene Name: MORF4L2
• UniProt Synonym Gene Names: KIAA0026; MRGX
• UniProt Entry Name: MO4L2_HUMAN

Uniprot Description

MORF4L2: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: nucleoplasm; nucleolus

Molecular Function: protein binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of striated muscle cell differentiation; chromatin modification; DNA repair