Rabbit anti-Mouse Monocarboxylate Transporter 8 Polyclonal Antibody | anti-SLC16A2 antibody

Monocarboxylate Transporter 8 (MCT8, XPCT)

Cat. Num. AAA616486

• Gene Names: SLC16A2; AHDS; MCT7; MCT8; XPCT; MCT 7; MCT 8; MRX22; DXS128; DXS128E
• Reactivity: Mouse
• Applications: ELISA
• Purity: Serum; Serum
• Synonyms: Monocarboxylate Transporter 8; Polyclonal Antibody; Monocarboxylate Transporter 8 (MCT8; XPCT); Anti -Monocarboxylate Transporter 8 (MCT8; anti-SLC16A2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse Monocarboxylate Transporter 8.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, 0.05% sodium azide.

• Applicable Applications for anti-SLC16A2 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
• Immunogen: A 19aa synthetic peptide corresponding to within the Cytoplasmic, C-terminus of mouse MCT8 coupled to KLH. Species sequence homology: rat-94%, human-89%.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SLC16A2 antibody

Monocarboxylate such as lactate and pyruvate play an important role in cellular metabolism. Lactic acid is produced as the end product of glycolysis. Some tissues, such as white skeletal muscle and, red blood cells, use this pathway to generate most of their ATP under normal physiological conditions. All tissues become dependent on this pathway during abnormal conditions such as hypoxia and ischaemia. Lactic acid, produced during normal glycolysis, must be transported out of cells to sustain maintain high rate of glycolysis. Failure to export lactic acid leads to accumulation of cellular lactic acid followed by an increase in pH and inhibition of glycolysis. Some tissues, such as brain, heart, and red skeletal muscle, readily oxidize lactic acid, and must import lactic acid into the cells. Lactic acid transport is mediated by a group of proton-linked membrane transporters called monocarboxylic acid transporters (MCTs). At least 9 MCT-related proteins (MCT1-9) have been identified in mammals that are expressed in a tissue specific manner. MCT8 or XPCT (X-linked PEST Containing Transporter; (mouse, 545 aa, human 613/598 aa, chromosome xq13.2) is highly expressed in liver, heart, and kidney.

Product Categories/Family for anti-SLC16A2 antibody

Antibodies; Abs to Monocarboxylate Transporter

NCBI and Uniprot Product Information

• NCBI GI #: 5730045
• NCBI GeneID: 6567
• NCBI Accession #: NP_006508.1
• NCBI GenBank Nucleotide #: NM_006517.3
• UniProt Accession #: P36021; Q7Z797
• Molecular Weight: 59,511 Da
• NCBI Official Full Name: monocarboxylate transporter 8
• NCBI Official Synonym Full Names: solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
• NCBI Official Symbol: SLC16A2
• NCBI Official Synonym Symbols: AHDS; MCT7; MCT8; XPCT; MCT 7; MCT 8; MRX22; DXS128; DXS128E
• NCBI Protein Information: monocarboxylate transporter 8; OTTHUMP00000023573; monocarboxylate transporter 7; solute carrier family 16 member 2; X-linked PEST-containing transporter
• UniProt Protein Name: Monocarboxylate transporter 8
• Protein Family: Monocarboxylate transporter
• UniProt Gene Name: SLC16A2
• UniProt Synonym Gene Names: MCT8; XPCT
• UniProt Entry Name: MOT8_HUMAN

NCBI Description

This gene encodes an integral membrane protein transporter of thyroid hormone; specifically, cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues including brain, heart, placenta, lung, kidney, skeletal muscle, and liver. This gene likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. [provided by RefSeq]

Uniprot Description

SLC16A2: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency); also known as Allan-Herndon-Dudley syndrome (AHDS). MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq13.2

Cellular Component: membrane; integral to plasma membrane; integral to membrane

Molecular Function: thyroid hormone transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity; transporter activity; symporter activity

Biological Process: monocarboxylic acid transport; transport

Disease: Allan-herndon-dudley Syndrome