Rabbit anti-Human Monocarboxylate Transporter 3 Polyclonal Antibody | anti-SLC16A8 antibody

Monocarboxylate Transporter 3 (MCT3)

Cat. Num. AAA618445

• Gene Names: SLC16A8; MCT3; REMP
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: Monocarboxylate Transporter 3; Polyclonal Antibody; Monocarboxylate Transporter 3 (MCT3); Anti -Monocarboxylate Transporter 3 (MCT3); anti-SLC16A8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Monocarboxylate Transporter 3 (MCT3). Species sequence homology: Not suitable for use in rat and mouse
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, 0.05% sodium azide.

• Applicable Applications for anti-SLC16A8 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of M4470-21A control peptide/well.
• Immunogen: Synthetic peptide corresponding to a 14aa sequence within the cytoplasmic, C-terminus of human MCT3 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SLC16A8 antibody

Monocarboxylate such as lactate and pyruvate play an important role in cellular metabolism. Lactic acid is produced as the end product of glycolysis. Some tissues, such as white skeletal muscle and, red blood cells, use this pathway to generate most of their ATP under normal physiological conditions. All tissues become dependent on this pathway during abnormal conditions such as hypoxia and ischaemia. Lactic acid, produced during normal glycolysis, must be transported out of cells to sustain maintain high rate of glycolysis. Failure to export lactic acid leads to accumulation of cellular lactic acid followed by an increase in pH and inhibition of glycolysis. Some tissues, such as brain, heart, and red skeletal muscle, readily oxidize lactic acid, and must import lactic acid into the cells. Lactic acid transport is mediated by a group of proton-linked membrane transporters called monocarboxylic acid transporters (MCTs). At least 9 MCT-related proteins (MCT1-9) have been identified in mammals that are expressed in a tissue specific manner. MCT3/REMP/SLC16A8 (mouse/rat 492-aa, human 504-aa; chromosome 22q12.3-q13.2) is exclusively located in the basal membrane of RPE, in contrast with MCT1, which was found on the apical surface. According to new nomenclature, the old MCT3 has now been reclassified as MCT4. Please consult the main MCT page and Halestrap AP and Price NT (1999) Biochem J. 343, 281-299 (review) for a detailed nomenclature.

Product Categories/Family for anti-SLC16A8 antibody

Antibodies; Abs to Monocarboxylate Transporter

NCBI and Uniprot Product Information

• NCBI GI #: 114796626
• NCBI GeneID: 23539
• NCBI Accession #: NP_037488.2
• NCBI GenBank Nucleotide #: NM_013356.2
• UniProt Accession #: O95907; Q9UBE2
• Molecular Weight: 52,319 Da
• NCBI Official Full Name: monocarboxylate transporter 3
• NCBI Official Synonym Full Names: solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
• NCBI Official Symbol: SLC16A8
• NCBI Official Synonym Symbols: MCT3; REMP
• NCBI Protein Information: monocarboxylate transporter 3; MCT 3; OTTHUMP00000199351; solute carrier family 16 member 8; solute carrier 16 (monocarboxylic acid transporters), member 8
• UniProt Protein Name: Monocarboxylate transporter 3
• Protein Family: Monocarboxylate transporter
• UniProt Gene Name: SLC16A8
• UniProt Synonym Gene Names: MCT3
• UniProt Entry Name: MOT3_HUMAN

NCBI Description

SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM]

Uniprot Description

SLC16A8: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q12.3-q13.2

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity

Biological Process: cellular metabolic process; lactate transport; pyruvate metabolic process; blood coagulation; transmembrane transport; leukocyte migration