Rabbit anti-Human, Mouse MOB1B Polyclonal Antibody | anti-MOB1B antibody

MOB1B Antibody

Cat. Num. AAA7130899

• Gene Names: MOB1B; MATS2; MOB4A; MOBKL1A
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: MOB1B; Polyclonal Antibody; MOB1B Antibody; MATS2; MOB1; Mps One Binder kinase activator-like 1A; anti-MOB1B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; Rabbit IgG In Phosphate Buffered Saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.

• Applicable Applications for anti-MOB1B antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:3000
• Immunogen: Synthesized peptide derived from internal of human MOL1A.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blot analysis of extracts from 293 cells, COS-7 cells and HUVEC cells all treated with IFN (2500U/ml, 30mins), using MOL1A antibody. )

Product Categories/Family for anti-MOB1B antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 348041379
• NCBI GeneID: 92597
• NCBI Accession #: NP_001231695.1
• NCBI GenBank Nucleotide #: NM_001244766.1
• UniProt Accession #: Q7L9L4; Q8IY23; B2R8U6; B4DRY3
• Molecular Weight: 25,091 Da
• NCBI Official Full Name: MOB kinase activator 1B isoform 1
• NCBI Official Synonym Full Names: MOB kinase activator 1B
• NCBI Official Symbol: MOB1B
• NCBI Official Synonym Symbols: MATS2; MOB4A; MOBKL1A
• NCBI Protein Information: MOB kinase activator 1B; mob1A; mob1 homolog 1A; MOB1 Mps One Binder homolog B; mps one binder kinase activator-like 1A; MOB1, Mps One Binder kinase activator-like 1A
• UniProt Protein Name: MOB kinase activator 1B
• Protein Family: MOB kinase activator
• UniProt Gene Name: MOB1B
• UniProt Synonym Gene Names: MOB4A; MOBKL1A; Mob1A
• UniProt Entry Name: MOB1B_HUMAN

NCBI Description

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Description

MOB1B: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Binds STK38L. Interacts with LATS1 and LATS2. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Belongs to the MOB1/phocein family.

Protein type: Activator; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; metal ion binding; kinase activator activity; kinase binding

Biological Process: protein amino acid autophosphorylation; positive regulation of phosphorylation