Western Blot (WB)
(The anti-MMP25 C-term Antibody is used in Western blot to detect MMP25 in mouse liver tissue lysate (lane 1) and HL60 cell lysate (lane 2) lysate.)
Rabbit anti-Human, mouse MMP25 Polyclonal Antibody | anti-MMP25 antibody
MMP25 Antibody (C-term)
Western Blot (WB)
(The anti-MMP25 C-term Antibody is used in Western blot to detect MMP25 in mouse liver tissue lysate (lane 1) and HL60 cell lysate (lane 2) lysate.)
Western Blot (WB)
(The anti-MMP25 C-term Antibody is used in Western blot to detect MMP25 in mouse liver tissue lysate (lane 1) and HL60 cell lysate (lane 2) lysate.)
Velasco, G., et al., Cancer Res. 60(4):877-882 (2000).
Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).
Pei, D., Cell Res. 9(4):291-303 (1999).
Kojima, S., et al., FEBS Lett. 480 (2-3), 142-146 (2000).
NCBI and Uniprot Product Information
NCBI Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Uniprot Description
MMP25: May activate progelatinase A. Belongs to the peptidase M10A family.
Protein type: EC 3.4.24.-; Membrane protein, GPI anchor; Cell surface; Membrane protein, integral; Activator; Protease
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: proteinaceous extracellular matrix; membrane; plasma membrane; integral to membrane
Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding
Biological Process: hard palate development; inflammatory response; proteolysis
Research Articles on MMP25
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Product Notes
The MMP25 mmp25 (Catalog #AAA9210375) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 470-499. The MMP25 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MMP25 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MMP25 mmp25 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMP25, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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