Western Blot (WB)
(Anti-MMP24 antibody, MBS176802, Western blottingLane 1: PANC Cell LysateLane 2: HELA Cell LysateLane 3: SMMC Cell LysateLane 4: A549 Cell Lysate )
Rabbit MMP24 Polyclonal Antibody | anti-MMP24 antibody
Anti-MMP24 antibody
Predicted to work with: Mouse, Rat
Predicted to work with: Mouse, Rat
Concentration: 0.1-0.5ug/ml
Tested Species: Hu
Predicted Species: Ms, Rat
Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Western Blot (WB)
(Anti-MMP24 antibody, MBS176802, Western blottingLane 1: PANC Cell LysateLane 2: HELA Cell LysateLane 3: SMMC Cell LysateLane 4: A549 Cell Lysate )
Western Blot (WB)
(Anti-MMP24 antibody, MBS176802, Western blottingLane 1: PANC Cell LysateLane 2: HELA Cell LysateLane 3: SMMC Cell LysateLane 4: A549 Cell Lysate )
Background: Matrix metalloproteinase-24, also known as MT5MMP or MMP25, is an enzyme that in humans is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase(MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP(MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. This gene may be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans.
NCBI and Uniprot Product Information
NCBI Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]
Uniprot Description
MMP24: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Belongs to the peptidase M10A family.
Protein type: Membrane protein, integral; EC 3.4.24.-; Activator; Protease
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane; trans-Golgi network membrane
Molecular Function: zinc ion binding; cadherin binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding
Biological Process: positive regulation of catalytic activity; glial cell differentiation; proteolysis; detection of temperature stimulus involved in sensory perception of pain
Research Articles on MMP24
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Product Notes
The MMP24 mmp24 (Catalog #AAA176802) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MMP24 antibody reacts with Reacts with: Human Predicted to work with: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MMP24 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot (WB): Concentration: 0.1-0.5ug/ml Tested Species: Hu Predicted Species: Ms, Rat Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. . Researchers should empirically determine the suitability of the MMP24 mmp24 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMP24, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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