Rabbit anti-Human MLLT10 Polyclonal Antibody | anti-MLLT10 antibody

Rabbit Polyclonal to Human MLLT10

Cat. Num. AAA241049

• Gene Names: MLLT10; AF10
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Protein G Purified
• Synonyms: MLLT10; Polyclonal Antibody; Rabbit Polyclonal to Human MLLT10; Anti-MLLT10 Antibody (aa1013-1027) IHC-plus; AF10; Protein AF-10; Type I AF10 protein; Type III AF10 protein; Translocated to; 10; Type IV AF10 protein; Human MLLT10; anti-MLLT10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Amino acids 1013 to 1027 of human MLLT10
• Purity/Purification: Protein G Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1027

• Applicable Applications for anti-MLLT10 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:000 - 1:1000), IHC-P (5 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human MLLT10 / AF10.
• Immunogen Type: Synthetic peptide
• Immunogen: MLLT10 antibody was raised against synthetic peptide from human MLLT10 / AF10.
• Antigen Modification: aa1013-1027
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-MLLT10 / AF10 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4757726
• NCBI GeneID: 8028
• NCBI Accession #: NP_004632.1
• NCBI GenBank Nucleotide #: NM_004641.3
• UniProt Accession #: P55197; Q5JT37; Q5VX90; Q66K63; B1ANA8
• Molecular Weight: 20,047 Da
• NCBI Official Full Name: protein AF-10 isoform a
• NCBI Official Synonym Full Names: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
• NCBI Official Symbol: MLLT10
• NCBI Official Synonym Symbols: AF10
• NCBI Protein Information: protein AF-10; type I AF10 protein; type IV AF10 protein; type III AF10 protein; ALL1-fused gene from chromosome 10 protein
• UniProt Protein Name: Protein AF-10
• Protein Family: Protein
• UniProt Gene Name: MLLT10
• UniProt Synonym Gene Names: AF10
• UniProt Entry Name: AF10_HUMAN

NCBI Description

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Description

MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; DNA binding; zinc ion binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: Leukemia, Acute Myeloid