Western Blot (WB)
(Western Blot analysis of MLF1 in Mouse heart tissue, Human cerebrum tissue, Human cerebella tissue lysates in order using MLF1 Rabbit pAb at dilution 1/800)
Rabbit anti-Human, Mouse MLF1 Polyclonal Antibody | anti-MLF1 antibody
MLF1 Rabbit pAb
Western Blot (WB)
(Western Blot analysis of MLF1 in Mouse heart tissue, Human cerebrum tissue, Human cerebella tissue lysates in order using MLF1 Rabbit pAb at dilution 1/800)
Western Blot (WB)
(Western Blot analysis of MLF1 in Mouse heart tissue, Human cerebrum tissue, Human cerebella tissue lysates in order using MLF1 Rabbit pAb at dilution 1/800)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Uniprot Description
MLF1: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM. Belongs to the MLF family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein domain specific binding; protein binding; DNA binding
Biological Process: myeloid progenitor cell differentiation; transcription, DNA-dependent; cell cycle arrest
Disease: Leukemia, Acute Myeloid
Research Articles on MLF1
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Product Notes
The MLF1 mlf1 (Catalog #AAA4759383) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MLF1 Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MLF1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the MLF1 mlf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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