Western Blot (WB)
(Mouse Mknk2 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mknk2 antibody detected the Mknk2 protein (arrow).)
Rabbit Mknk2 Polyclonal Antibody | anti-Mknk2 antibody
Mouse Mknk2 Antibody (N-term)
Western Blot (WB)
(Mouse Mknk2 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mknk2 antibody detected the Mknk2 protein (arrow).)
Western Blot (WB)
(Mouse Mknk2 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mknk2 antibody detected the Mknk2 protein (arrow).)
Furic, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14134-14139(2010)
Joshi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):12097-12102(2009)
Chrestensen, C.A., et al. Genes Cells 12(10):1133-1140(2007)
Shenberger, J.S., et al. Int. J. Biochem. Cell Biol. 39(10):1828-1842(2007)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]
Uniprot Description
Mnk2: a ubiquituous CAM kinase of the MAPKKAPK family. Regulates translation by phosphorylating S209 of eIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. The phosphorylation of eIF4E S209 by the MNK1/2 kinases is required for eIF4E's oncogenic action. Phosphorylates Spry2 on S112 and S121, leading to the ubiquitination and degradation of Spry2. Five splice-variant isoforms have been described.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Translation; Kinase, protein; CAMK group; MAPKAPK family; MNK subfamily
Cellular Component: nucleoplasm; cytoplasm; nucleolus; intracellular; nucleus
Molecular Function: calmodulin binding; transferase activity; protein serine/threonine kinase activity; protein binding; calcium-dependent protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: regulation of translation; peptidyl-serine phosphorylation; apoptosis; protein amino acid autophosphorylation; hemopoiesis; protein amino acid phosphorylation; phosphorylation
Research Articles on Mknk2
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Product Notes
The Mknk2 mknk2 (Catalog #AAA9212680) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 36-64. The Mouse Mknk2 Antibody (N-term) reacts with Mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Mknk2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Mknk2 mknk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mknk2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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