Loading...

Skip to main content

Call us on + 1 (800) 604-9114 for more information about our products

Rabbit anti-Human Mitogen Activated Protein Kinase 10 (MAPK10) Polyclonal Antibody | anti-MAPK10 antibody

Biotin-Linked Antibody to Mitogen Activated Protein Kinase 10 (MAPK10)

Gene Names
Mapk10; Jnk3; SAPb; SAPKC; Serk2
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Affinity Chromatography
Synonyms
Mitogen Activated Protein Kinase 10 (MAPK10); Polyclonal Antibody; Biotin-Linked Antibody to Mitogen Activated Protein Kinase 10 (MAPK10); anti-MAPK10 antibody
Ordering
 
When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures.
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody is a rabbit polyclonal antibody raised against MAPK10 conjugated to biotin. It has been selected for its ability to recognize MAPK10 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
500ug/ml (varies by lot)
Sequence Length
426
Applicable Applications for anti-MAPK10 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Product Categories/Family for anti-MAPK10 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
52,530 Da
NCBI Official Full Name
mitogen-activated protein kinase 10 isoform 2
NCBI Official Synonym Full Names
mitogen activated protein kinase 10
NCBI Official Symbol
Mapk10
NCBI Official Synonym Symbols
Jnk3; SAPb; SAPKC; Serk2
NCBI Protein Information
mitogen-activated protein kinase 10; MAPK 10; p54-beta; SAPK-beta; MAP kinase 10; c-Jun N-terminal kinase 3; Stress activated protein kinase beta; stress-activated protein kinase JNK3
UniProt Protein Name
Mitogen-activated protein kinase 10
UniProt Gene Name
Mapk10
UniProt Synonym Gene Names
Jnk3; Prkm10; MAP kinase 10; MAPK 10
UniProt Entry Name
MK10_RAT

NCBI Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, apoptosis, inflammation and transformation. This protein plays regulatory roles in the signaling pathways during neuronal apoptosis. It is required for both axonal regeneration and survival. This gene is one of the serum-response factor (SRF) regulated target genes and is implicated in cardiovascular formation. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

JNK3: a protein kinase of the MAPK family that is potently activated by a variety of environmental stress and pro-inflammatory cytokines. Brain-selective JNK isoform. A pro-apoptotic protein and potential tumor suppressor. Phosphorylates a number of transcription factors including c-Jun, ATF2 and ELK1. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity. CDK5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Interacts with HDAC9. Expression lost in brain tumors. May function in neuronal cell death from injury and neurodegeneration, for which inhibitors are being developed. Two alternatively spliced transcript variants have been reported.

Protein type: Protein kinase, CMGC; Kinase, protein; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; MAPK/JNK subfamily; JNK subfamily

Cellular Component: mitochondrion; cytoplasm; plasma membrane; nucleus

Molecular Function: MAP kinase activity; protein binding; JUN kinase activity; ATP binding

Biological Process: locomotor rhythm; response to light stimulus; MAPKKK cascade; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; protein amino acid phosphorylation; JUN phosphorylation

Research Articles on MAPK10

Similar Products

Product Notes

The MAPK10 mapk10 (Catalog #AAA2006792) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Antibody to Mitogen Activated Protein Kinase 10 (MAPK10) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Mitogen Activated Protein Kinase 10 (MAPK10) can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the MAPK10 mapk10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mitogen Activated Protein Kinase 10 (MAPK10), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
Looking for a specific manual?
Request a Manual