Rabbit anti-Human Mitogen Activated Protein Kinase 10 (MAPK10) Polyclonal Antibody | anti-MAPK10 antibody

Biotin-Linked Antibody to Mitogen Activated Protein Kinase 10 (MAPK10)

Cat. Num. AAA2006792

• Gene Names: Mapk10; Jnk3; SAPb; SAPKC; Serk2
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Affinity Chromatography
• Synonyms: Mitogen Activated Protein Kinase 10 (MAPK10); Polyclonal Antibody; Biotin-Linked Antibody to Mitogen Activated Protein Kinase 10 (MAPK10); anti-MAPK10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody is a rabbit polyclonal antibody raised against MAPK10 conjugated to biotin. It has been selected for its ability to recognize MAPK10 in immunohistochemical staining andwestern blotting.
• Purity/Purification: Affinity Chromatography
• Form/Format: Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
• Concentration: 500ug/ml (varies by lot)
• Sequence Length: 426

• Applicable Applications for anti-MAPK10 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: Western blotting: 1:100-400; Immunocytochemistry in formalin fixed cells: 1:100-500; Immunohistochemistry in formalin fixed frozen section: 1:100-500; Immunohistochemistry in paraffin section: 1:50-200; Enzyme-linked Immunosorbent Assay: 1:100-200
• Preparation and Storage: Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Product Categories/Family for anti-MAPK10 antibody

Biotin Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 395759215
• NCBI GeneID: 25272
• NCBI Accession #: NP_036938.2
• NCBI GenBank Nucleotide #: NM_012806.2
• UniProt Accession #: P49187
• Molecular Weight: 52,530 Da
• NCBI Official Full Name: mitogen-activated protein kinase 10 isoform 2
• NCBI Official Synonym Full Names: mitogen activated protein kinase 10
• NCBI Official Symbol: Mapk10
• NCBI Official Synonym Symbols: Jnk3; SAPb; SAPKC; Serk2
• NCBI Protein Information: mitogen-activated protein kinase 10; MAPK 10; p54-beta; SAPK-beta; MAP kinase 10; c-Jun N-terminal kinase 3; Stress activated protein kinase beta; stress-activated protein kinase JNK3
• UniProt Protein Name: Mitogen-activated protein kinase 10
• UniProt Gene Name: Mapk10
• UniProt Synonym Gene Names: Jnk3; Prkm10; MAP kinase 10; MAPK 10
• UniProt Entry Name: MK10_RAT

NCBI Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, apoptosis, inflammation and transformation. This protein plays regulatory roles in the signaling pathways during neuronal apoptosis. It is required for both axonal regeneration and survival. This gene is one of the serum-response factor (SRF) regulated target genes and is implicated in cardiovascular formation. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

JNK3: a protein kinase of the MAPK family that is potently activated by a variety of environmental stress and pro-inflammatory cytokines. Brain-selective JNK isoform. A pro-apoptotic protein and potential tumor suppressor. Phosphorylates a number of transcription factors including c-Jun, ATF2 and ELK1. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity. CDK5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Interacts with HDAC9. Expression lost in brain tumors. May function in neuronal cell death from injury and neurodegeneration, for which inhibitors are being developed. Two alternatively spliced transcript variants have been reported.

Protein type: Protein kinase, CMGC; Kinase, protein; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; MAPK/JNK subfamily; JNK subfamily

Cellular Component: mitochondrion; cytoplasm; plasma membrane; nucleus

Molecular Function: MAP kinase activity; protein binding; JUN kinase activity; ATP binding

Biological Process: locomotor rhythm; response to light stimulus; MAPKKK cascade; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; protein amino acid phosphorylation; JUN phosphorylation