Rabbit anti-Human Mitogen Activated Protein Kinase 10 (MAPK10) Polyclonal Antibody | anti-MAPK10 antibody
Biotin-Linked Antibody to Mitogen Activated Protein Kinase 10 (MAPK10)
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, apoptosis, inflammation and transformation. This protein plays regulatory roles in the signaling pathways during neuronal apoptosis. It is required for both axonal regeneration and survival. This gene is one of the serum-response factor (SRF) regulated target genes and is implicated in cardiovascular formation. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
JNK3: a protein kinase of the MAPK family that is potently activated by a variety of environmental stress and pro-inflammatory cytokines. Brain-selective JNK isoform. A pro-apoptotic protein and potential tumor suppressor. Phosphorylates a number of transcription factors including c-Jun, ATF2 and ELK1. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity. CDK5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Interacts with HDAC9. Expression lost in brain tumors. May function in neuronal cell death from injury and neurodegeneration, for which inhibitors are being developed. Two alternatively spliced transcript variants have been reported.
Protein type: Protein kinase, CMGC; Kinase, protein; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; MAPK/JNK subfamily; JNK subfamily
Cellular Component: mitochondrion; cytoplasm; plasma membrane; nucleus
Molecular Function: MAP kinase activity; protein binding; JUN kinase activity; ATP binding
Biological Process: locomotor rhythm; response to light stimulus; MAPKKK cascade; JNK cascade; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; protein amino acid phosphorylation; JUN phosphorylation