Western Blot (WB)
(Host: MouseTarget Name: MITFSample Tissue: Mouse LiverAntibody Dilution: 1ug/ml)
Rabbit MITF Polyclonal Antibody | anti-MITF antibody
MITF antibody - middle region
Western Blot (WB)
(Host: MouseTarget Name: MITFSample Tissue: Mouse LiverAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: MouseTarget Name: MITFSample Tissue: Mouse LiverAntibody Dilution: 1ug/ml)
Western Blot (WB)
(WB Suggested Anti-MITF Antibody Titration: 0.2-1 ug/mlPositive Control: Hela cell lysateMITF is supported by BioGPS gene expression data to be expressed in HeLa)
Western Blot (WB)
(WB Suggested Anti-MITF Antibody Titration: 0.2-1 ug/mlPositive Control: Hela cell lysateMITF is supported by BioGPS gene expression data to be expressed in HeLa)
Target Description: MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]
Uniprot Description
MITF: a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Plays a critical role in the differentiation of various cell types including neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Two isoforms are known: the M-isoform is expressed exclusively in melanocytes, while the A-isoform has a much broader range of expression. Mutations in MITF can lead to Waardenburg syndrome. Ten alternatively spliced isoforms have been described.
Protein type: DNA-binding; Transcription factor; Oncoprotein
Chromosomal Location of Human Ortholog: 3p14.2-p14.1
Cellular Component: protein complex; nucleus
Molecular Function: protein dimerization activity; RNA polymerase II transcription factor activity, enhancer binding; protein binding; chromatin binding
Biological Process: transcription from RNA polymerase II promoter; cell fate commitment; camera-type eye development; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; melanocyte differentiation; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; negative regulation of transcription from RNA polymerase II promoter; bone remodeling; regulation of cell proliferation
Disease: Albinism, Ocular, With Sensorineural Deafness; Waardenburg Syndrome, Type 2a; Melanoma, Cutaneous Malignant, Susceptibility To, 8; Tietz Syndrome
Research Articles on MITF
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Product Notes
The MITF mitf (Catalog #AAA3203835) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MITF antibody - middle region reacts with Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's MITF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the MITF mitf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: MGSKLEDILM DDTLSPVGVT DPLLSSVSPG ASKTSSRRSS MSMEETEHTC. It is sometimes possible for the material contained within the vial of "MITF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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