Western Blot (WB)
(Western Blot: Sample: Human Hela Cells.)
Rabbit anti-Human Microtubule Associated Protein Tau Polyclonal Antibody | anti-MAPt antibody
Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- K VVQEGFLREPGPPGLSHQLM SGMPGAPLLP EGPREATRQP SGTGPEDTEG GRHAPELLKH QLLGDLHQEG PPLKGAGGKE RPGSKEEVDE DRDVDESSPQ DSPPSKASPA QDGRPPQTAA REATSIPGFP AEGAIPLPVD FLSKVSTEIP ASEPDGPSVG RAKGQDAPLE FTFHVEITPN VQKEQAHSEE HLGRAAFPGA PGEGPEARGP SLGEDTKEAD LPEPSEKQPAAAPRGKPVSR VPQLKARMVS KSKDGT
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Human Hela Cells.)
Western Blot (WB)
(Western Blot: Sample: Human Hela Cells.)
Western Blot (WB)
(Western Blot: Sample: Recombinant MAPt, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant MAPt, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Glioma Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Glioma Tissue)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Uniprot Description
Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: axolemma; axon; axon cytoplasm; cell body; cell soma; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; dendrite; growth cone; membrane; microtubule; microtubule associated complex; microtubule cytoskeleton; nuclear periphery; nuclear speck; nucleus; plasma membrane; somatodendritic compartment; tubulin complex
Molecular Function: actin binding; apolipoprotein binding; DNA binding; enzyme binding; Hsp90 protein binding; identical protein binding; lipoprotein particle binding; microtubule binding; protein binding; protein homodimerization activity; protein phosphatase 2A binding; receptor ligand activity; SH3 domain binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; amyloid fibril formation; astrocyte activation; axonal transport; axonal transport of mitochondrion; cellular response to heat; cytoplasmic microtubule organization; generation of neurons; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization; negative regulation of gene expression; negative regulation of kinase activity; negative regulation of mitochondrial fission; negative regulation of mitochondrial membrane potential; neuron projection development; plus-end-directed organelle transport along microtubule; positive regulation of axon extension; positive regulation of diacylglycerol kinase activity; positive regulation of microtubule polymerization; positive regulation of neuron death; positive regulation of superoxide anion generation; protein oligomerization; regulation of autophagy; regulation of cellular response to heat; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of mitochondrial fission; regulation of receptor activity; regulation of response to DNA damage stimulus; synapse organization
Disease: Frontotemporal Dementia; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Parkinson Disease, Late-onset; Parkinson-dementia Syndrome; Pick Disease Of Brain; Supranuclear Palsy, Progressive, 1
Research Articles on MAPt
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Product Notes
The MAPt mapt (Catalog #AAA2027217) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Microtubule Associated Protein Tau can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-5ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the MAPt mapt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- K VVQEGFLREP GPPGLSHQLM SGMPGAPLLP EGPREATRQP SGTGPEDTEG GRHAPELLKH QLLGDLHQEG PPLKGAGGKE RPGSKEEVDE DRDVDESSPQ DSPPSKASPA QDGRPPQTAA REATSIPGFP AEGAIPLPVD FLSKVSTEIP ASEPDGPSVG RAKGQDAPLE FTFHVEITPN VQKEQAHSEE HLGRAAFPGA PGEGPEARGP SLGEDTKEAD LPEPSEKQPA AAPRGKPVSR VPQLKARMVS KSKDGT. It is sometimes possible for the material contained within the vial of "Microtubule Associated Protein Tau, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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