Rabbit MGAT3 Polyclonal Antibody | anti-MGAT3 antibody
MGAT3 Antibody
Gene Names
MGAT3; GNT3; GNT-III
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
MGAT3; Polyclonal Antibody; MGAT3 Antibody; 4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; Beta 1 4 mannosyl glycoprotein 4 beta N acetylglucosaminyltransferase; Beta-1; FLJ43371; GlcNAc T III; GlcNAc-T III; GNT 3; GNT III; GNT-III; GNT3; Mannosyl (beta 1 4) glycoprotein beta 1 4 N acetylglucosaminyltransferase; MGAT 3; MGAT3_HUMAN; MGC141943; MGC142278; N acetylglucosaminyltransferase III; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase III; N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; OTTHUMP00000042207; anti-MGAT3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
MGAT3 Antibody detects endogenous levels of MGAT3.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-MGAT3 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human MGAT3.
Conjugation
Unconjugated
Similarity
Belongs to the glycosyltransferase 17 family.
Subunit Structure
Interacts with MGAT4D.
Function
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1, 6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate. Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location. Inhibits NeuAc-alpha-2, 3-Gal-beta-1, 4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation. In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (By similarity).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-MGAT3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
61,313 Da
NCBI Official Full Name
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
NCBI Official Synonym Full Names
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
NCBI Official Symbol
MGAT3
NCBI Official Synonym Symbols
GNT3; GNT-III
NCBI Protein Information
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; GlcNAc-T III; N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
UniProt Protein Name
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
UniProt Gene Name
MGAT3
UniProt Synonym Gene Names
GGNT3; GNT-III; GlcNAc-T III; N-acetylglucosaminyltransferase III
UniProt Entry Name
MGAT3_HUMAN
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Product Notes
The MGAT3 mgat3 (Catalog #AAA9630548) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MGAT3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MGAT3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the MGAT3 mgat3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MGAT3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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