Sheep Methotrexate Polyclonal Antibody | anti-Slc19a1 antibody
Methotrexate
Gene Names
Slc19a1; MTX1
Applications
ELISA, Western Blot, Dot Blot, Immunohistochemistry
Synonyms
Methotrexate; Polyclonal Antibody; MTX; amethopterin; anti-Slc19a1 antibody
Host
Sheep
Clonality
Polyclonal
Form/Format
Ig Fraction - Liquid
Concentration
>5mg/ml (U.V.abs @ 280nm) (varies by lot)
Sequence Length
512
Applicable Applications for anti-Slc19a1 antibody
ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunohistochemistry (IHC), Immunoassays, Development of Rapid tests and Other Immunoassay, Antibody Recognition Assays
Immunogen
Methotrexate-BSA
Buffer
20mM Phosphate, 150mM Sodium Chloride
Preservative
0.09% Sodium Azide
Preparation and Storage
Upon delivery aliquot and store at -20 degree C. Avoid freeze / thaw cycles. Short term storage 2 - 8 degree C.
Related Product Information for anti-Slc19a1 antibody
Methotrexate (rINN) abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases and as an abortifacient in the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about one thousand-fold that of folate for DHFR. Methotrexate acts specifically during DNA and RNA synthesis, and thus it is cytotoxic during the S-phase of the cell cycle. Logically, it therefore has a greater toxic effect on rapidly dividing cells which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells. Lower doses of methotrexate have been shown to be very effective for the management of rheumatoid arthritis, Crohn's disease, and psoriasis.
Product Categories/Family for anti-Slc19a1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
58,094 Da
NCBI Official Full Name
methotrexate carrier
NCBI Official Synonym Full Names
solute carrier family 19 member 1
NCBI Official Symbol
Slc19a1
NCBI Official Synonym Symbols
MTX1
NCBI Protein Information
folate transporter 1
UniProt Protein Name
Folate transporter 1
UniProt Gene Name
Slc19a1
UniProt Synonym Gene Names
RFC-1; RFC1
UniProt Entry Name
S19A1_RAT
NCBI Description
mouse homolog facilitates transport of methotrexate and folic acid [RGD, Feb 2006]
Uniprot Description
Transporter for the intake of folate, reduced folates and methotrexate.
Research Articles on Slc19a1
Similar Products
Product Notes
The Slc19a1 slc19a1 (Catalog #AAA340544) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Methotrexate can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunohistochemistry (IHC), Immunoassays, Development of Rapid tests and Other Immunoassay, Antibody Recognition Assays. Researchers should empirically determine the suitability of the Slc19a1 slc19a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Methotrexate, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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