Loading...

Skip to main content

Call us on + 1 (800) 604-9114 for more information about our products

Looking for specific datasheet Manual/COA/MSDS?
Request a Manual/COA/MSDS

Interested to get a quote about our products?
Request a Quote

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human testis using MBS7601368 (METAP2 antibody) at dilution of 1:50)

Rabbit METAP2 Polyclonal Antibody | anti-METAP2 antibody

METAP2 Rabbit Polyclonal

Gene Names
METAP2; MAP2; MNPEP; p67eIF2
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Synonyms
METAP2; Polyclonal Antibody; METAP2 Rabbit Polyclonal; anti-METAP2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
Sequence Length
455
Applicable Applications for anti-METAP2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen
Methionyl aminopeptidase 2
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis using MBS7601368 (METAP2 antibody) at dilution of 1:50)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human testis using MBS7601368 (METAP2 antibody) at dilution of 1:50)

Western Blot (WB)

(HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7601368 (METAP2 antibody) at dilution of 1:300)

Western Blot (WB) (HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7601368 (METAP2 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
50,497 Da
NCBI Official Full Name
methionine aminopeptidase 2 isoform 3
NCBI Official Synonym Full Names
methionyl aminopeptidase 2
NCBI Official Symbol
METAP2
NCBI Official Synonym Symbols
MAP2; MNPEP; p67eIF2
NCBI Protein Information
methionine aminopeptidase 2
UniProt Protein Name
Methionine aminopeptidase 2
UniProt Gene Name
METAP2
UniProt Synonym Gene Names
MAP 2; MetAP 2; p67; p67eIF2
UniProt Entry Name
MAP2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

METAP2: Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Interacts strongly with the eIF-2 gamma-subunit EIF2S3. Binds EIF2S1 at low magnesium concentrations. Belongs to the peptidase M24A family.

Protein type: Protease; EC 3.4.11.18

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function: aminopeptidase activity; metal ion binding; metalloexopeptidase activity

Biological Process: N-terminal protein amino acid modification; peptidyl-methionine modification; protein processing; regulation of rhodopsin mediated signaling

Research Articles on METAP2

Similar Products

Product Notes

The METAP2 metap2 (Catalog #AAA7601368) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The METAP2 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's METAP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the METAP2 metap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "METAP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Item has been added to Shopping Cart

If you are ready to order, navigate to Shopping Cart and get ready to checkout.

Looking for a specific manual?
Request a Manual

Request more Information

Please complete the form below and a representative will contact you as soon as possible.

Request a Manual

Please complete the form below and a representative will contact you as soon as possible.

Request a Quote

Please complete the form below and a representative will contact you as soon as possible.