Rabbit METABOTROPIC GLUTAMATE RECEPTOR 1a Polyclonal Antibody | anti-Grm1 antibody

RABBIT ANTI RAT METABOTROPIC GLUTAMATE RECEPTOR 1a

Cat. Num. AAA224070

• Gene Names: Grm1; Gprc1a
• Applications: Immunohistochemistry, Western Blot
• Synonyms: METABOTROPIC GLUTAMATE RECEPTOR 1a; Polyclonal Antibody; RABBIT ANTI RAT METABOTROPIC GLUTAMATE RECEPTOR 1a; anti-Grm1 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This item recognises rat metabotropic glutamate receptor 1a (mGluR1a). The metabotropic glutamate receptors have been organised into three groups. mGluR5 and mGluR1 make up group I which, when activated, stimulates phospholipase C and activates protein kinase C to hydrolyse phosphoinositide phospholipids in the cell membrane. Group I mGluRs, but not other groups, are activated by 3, 5-dihydroxyphenylglycine (DHPG).
• Form/Format: Purified; Purified IgG - liquid
• Sequence Length: 906

• Applicable Applications for anti-Grm1 antibody: Immunohistology Frozen, Western Blot (WB)
• Application Notes: Western Blot: This item detects bands of approximately 125kDa (monomer) and 250kDa (dimer) on lysate from transfected HEK293 cells. This antibody has also been reported to detect bands at approximately 120kDa (reduced) and 210kD (non-reduced), in protein extracts from adult rat cerebellum.; Immunohistology - Frozen: Maximum Dilution: 1/500; Western Blotting: Maximum Dilution: 1/1000
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3); 0.01% Bovine Serum Albumin; 50% Glycerol
• Immunogen: Peptide corresponding to amino acids 1115-1130 from the C-terminal region of rat mGluR1a.; Buffer Solution
• Antiserum Preparation: Antisera to metabotropic glutamate receptor 1a were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
• Target Species: Rat
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-Grm1 antibody

MBS224070 recognises rat metabotropic glutamate receptor 1a (mGluR1a). The metabotropic glutamate receptors have been organised into three groups. mGluR5 and mGluR1 make up group I which, when activated, stimulates phospholipase C and activates protein kinase C to hydrolyse phosphoinositide phospholipids in the cell membrane. Group I mGluRs, but not other groups, are activated by 3, 5-dihydroxyphenylglycine (DHPG).

NCBI and Uniprot Product Information

• NCBI GI #: 166999225
• NCBI GeneID: 24414
• NCBI Accession #: NP_001107802.1
• NCBI GenBank Nucleotide #: NM_001114330.1
• UniProt Accession #: P23385
• Molecular Weight: 100,752 Da
• NCBI Official Full Name: metabotropic glutamate receptor 1 isoform beta
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 1
• NCBI Official Symbol: Grm1
• NCBI Official Synonym Symbols: Gprc1a
• NCBI Protein Information: metabotropic glutamate receptor 1; G protein coupled receptor family C group 1 member A; mGluR1
• UniProt Protein Name: Metabotropic glutamate receptor 1
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: Grm1
• UniProt Synonym Gene Names: Gprc1a; Mglur1; mGluR1
• UniProt Entry Name: GRM1_RAT

NCBI Description

may play a role in synaptic transmission; may modulate perception of pain in arthritis [RGD, Feb 2006]

Uniprot Description

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.