Western Blot (WB)
(WB Suggested Anti-MESP2 Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: SP2/0 cell lysate)
Rabbit anti-Mouse, Rat MESP2 Polyclonal Antibody | anti-MESP2 antibody
MESP2 antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-MESP2 Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: SP2/0 cell lysate)
Western Blot (WB)
(WB Suggested Anti-MESP2 Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: SP2/0 cell lysate)
Target Description: Somite boundaries formed during embryogenesis, at the interface between Notch1-activated and -repressed domains. Genetic and biochemical studies indicate that this interface is generated by suppression of Notch activity by mesoderm posterior 2 (Mesp2) through induction of the lunatic fringe gene (Lfng). It is proposed that the oscillation of Notch activity is arrested and translated in the wavefront by Mesp2.
NCBI and Uniprot Product Information
Uniprot Description
MESP2: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defects in MESP2 are the cause of spondylocostal dysostosis type 2 (SCDO2). An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Protein type: Transcription factor; Cell development/differentiation
Cellular Component: nucleus
Molecular Function: protein dimerization activity; DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; somitogenesis; Notch signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; mesodermal cell migration; somite rostral/caudal axis specification
Research Articles on MESP2
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Product Notes
The MESP2 mesp2 (Catalog #AAA3203369) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MESP2 antibody - C-terminal region reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MESP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the MESP2 mesp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: SCQRLQPQPQ PQPQWGCWGH DAEVLSTSED QGSSPALQLP VASPTPSSGL. It is sometimes possible for the material contained within the vial of "MESP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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