Rabbit MESP2 Polyclonal Antibody | anti-MESP2 antibody

MESP2 Polyclonal Antibody

Cat. Num. AAA3006922

• Gene Names: MESP2; SCDO2; bHLHc6
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: MESP2; Polyclonal Antibody; MESP2 Polyclonal Antibody; Mesoderm posterior protein 2; Class C basic helix-loop-helix protein 6; bHLHc6; BHLHC6; SCDO2; anti-MESP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MESP2 polyclonal antibody detects endogenous levels of MESP2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 397

• Applicable Applications for anti-MESP2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human MESP2
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of MESP2 polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysateLane2:sp2/0 whole cell lysate Lane3:H9C2 whole cell lysate)

Related Product Information for anti-MESP2 antibody

MESP2 (mesoderm posterior 2 homolog), also known as SCDO2 or bHLHc6 (class C basic helix-loop-helix protein 6), is a 397 amino acid protein that contains one basic helix-loop-helix (bHLH) domain, a motif that mediates protein dimerization and can bind to the E-box sequence of DNA. Localized to the nucleus, MESP2 functions as a transcription factor that, via its bHLH domain, participates in the epithelialization and the development of the cardiac and somitic mesoderm. MESP2 is involved in somitogenesis and Notch pathways and is encoded by a gene that maps to human chromosome 15q26.1. Defects in the MESP2 gene are the cause of an autosomal recessive disorder known as spondylocostal dysostosis type 2 (SCDO2).

NCBI and Uniprot Product Information

• NCBI GI #: 90403598
• NCBI GeneID: 145873
• NCBI Accession #: NP_001035047.1
• NCBI GenBank Nucleotide #: NP_001035047.1
• UniProt Accession #: Q0VG99
• Molecular Weight: ~ 42kDa
• NCBI Official Full Name: mesoderm posterior protein 2
• NCBI Official Synonym Full Names: mesoderm posterior bHLH transcription factor 2
• NCBI Official Symbol: MESP2
• NCBI Official Synonym Symbols: SCDO2; bHLHc6
• NCBI Protein Information: mesoderm posterior protein 2
• UniProt Protein Name: Mesoderm posterior protein 2
• Protein Family: Mesoderm posterior protein
• UniProt Gene Name: MESP2
• UniProt Synonym Gene Names: BHLHC6; SCDO2; bHLHc6

NCBI Description

This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]

Uniprot Description

MESP2: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defects in MESP2 are the cause of spondylocostal dysostosis type 2 (SCDO2). An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.

Protein type: Cell development/differentiation; Transcription factor

Chromosomal Location of Human Ortholog: 15q26.1

Disease: Spondylocostal Dysostosis 1, Autosomal Recessive; Spondylocostal Dysostosis 2, Autosomal Recessive