MEK Kinase-3 Polyclonal Antibody | anti-MAP3K3 antibody

MEK Kinase-3 Polyclonal Antibody

Cat. Num. AAA8523689

• Gene Names: MAP3K3; MEKK3; MAPKKK3
• Synonyms: MEK Kinase-3; Polyclonal Antibody; MEK Kinase-3 Polyclonal Antibody; anti-MAP3K3 antibody

• Clonality: Polyclonal
• Sequence Length: 626

NCBI and Uniprot Product Information

• NCBI GI #: 42794765
• NCBI GeneID: 4215
• NCBI Accession #: NP_002392.2
• NCBI GenBank Nucleotide #: NM_002401.3
• UniProt Accession #: Q99759; Q5BKZ6; Q8N3I9; B2RCW2; D3DU15
• Molecular Weight: 74,089 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase 3 isoform 2
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 3
• NCBI Official Symbol: MAP3K3
• NCBI Official Synonym Symbols: MEKK3; MAPKKK3
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 3
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 3
• UniProt Gene Name: MAP3K3
• UniProt Synonym Gene Names: MAPKKK3; MEKK3; MEK kinase 3; MEKK 3

NCBI Description

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.