Goat mei-41 Polyclonal Antibody | anti-mei-41 antibody

Goat anti-mei-41 (Drosophila melanogaster) Antibody

Gene Names

mei-41; 4252; atr; ATR; CG4252; DmATR; DmelCG4252; Dmmei41; fs(1)M37; mei-195; Mei-41; Mei-41/DATR; mei41; MEI41; MEI41/FRP1; meiP41; mus(1)103; mus(1)104; mus-103; mus-104; mus103; mus104

Reactivity

Expected from sequence similarity: Drosophila

Applications

ELISA

Purity

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Synonyms

mei-41; Polyclonal Antibody; Goat anti-mei-41 (Drosophila melanogaster) Antibody; meiotic 41; Dmel; CG4252; 4252; ATR; DmATR; Dmel\CG4252; Dmmei41; MEI41; MEI41/FRP1; Mei-41; Mei-41/DATR; atr; fs(1)M37; mei-195; mei41; meiP41; mus(1)103; mus(1)104; mus-103; mus-104; mus103; mus104; ATM-RAD3 related; CG4252-PA; drosophil; 4252 antibody; ATM-RAD3 related antibody; ATR antibody; atr antibody; CG4252 antibody; CG4252-PA antibody; DmATR antibody; Dmel antibody; Dmel\CG4252 antibody; Dmmei41 antibody; drosophila ATR antibody; fs(1)M37 antibody; mei-195 antibody; MEI41 antibody; mei41 antibody; Mei-41 antibody; Mei-41/DATR antibody; MEI41/FRP1 antibody; mei-41-PA antibody; meiotic 41 antibody; meiotic-41 antibody; meiP41 antibody; mus(1)103 antibody; mus(1)104 antibody; mus103 antibody; mus-103 antibody; mus104 antibody; mus-104 antibody; mei-41 antibody; mei-41 (Drosophila melanogaster); anti-mei-41 antibody

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Cat. Num. AAA422928 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

Goat

Reactivity

Expected from sequence similarity: Drosophila

Clonality

Polyclonal

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Concentration

100ug specific antibody in 200ul (varies by lot)

Sequence

DPHCAIEDIKVPLEQ

Sequence Length

2517

Applicable Applications for anti-mei-41 antibody

Peptide ELISA (EIA)

Application Notes

Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Not yet tested. At this stage we are dependent on researchers in the field for further characterization of this product. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product.

Immunogen

Peptide with sequence DPHCAIEDIKVPLEQ, from the internal region of the protein sequence according to NP_523369.2.

Epitope

Internal region

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

NCBI GI #

24642511

NCBI GeneID

32608

NCBI Accession #

NP_523369.2

NCBI GenBank Nucleotide #

NM_078645.3

Molecular Weight

289,330 Da

NCBI Official Full Name

meiotic 41

NCBI Official Synonym Full Names

meiotic 41

NCBI Official Symbol

mei-41

NCBI Official Synonym Symbols

4252; atr; ATR; CG4252; DmATR; DmelCG4252; Dmmei41; fs(1)M37; mei-195; Mei-41; Mei-41/DATR; mei41; MEI41; MEI41/FRP1; meiP41; mus(1)103; mus(1)104; mus-103; mus-104; mus103; mus104

NCBI Protein Information

CG4252 gene product from transcript CG4252-RA

UniProt Protein Name

Serine/threonine-protein kinase ATR

UniProt Gene Name

mei-41

UniProt Synonym Gene Names

ATR homolog; dATR

UniProt Entry Name

ATR_DROME

Uniprot Description

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. Essential for the DNA damage checkpoint in larval imaginal disks and neuroblasts and for the DNA replication checkpoint in the embryo. Has also an essential role during early nuclear divisions in embryos, where it is required to delay mitosis in response to incomplete DNA replication. Also plays an important role during meiosis, where it may monitor double-strand-break repair during meiotic crossing over, to regulate the progression of prophase I, and to enforce metaphase I delay observed at the end of oogenesis.

Research Articles on mei-41

1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

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Product Notes

The mei-41 mei-41 (Catalog #AAA422928) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-mei-41 (Drosophila melanogaster) Antibody reacts with Expected from sequence similarity: Drosophila and may cross-react with other species as described in the data sheet. AAA Biotech's mei-41 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Not yet tested. At this stage we are dependent on researchers in the field for further characterization of this product. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product. Researchers should empirically determine the suitability of the mei-41 mei-41 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: DPHCAIEDIK VPLEQ. It is sometimes possible for the material contained within the vial of "mei-41, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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