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Western Blot (WB) (Western blot analysis of MEF2C (arrow) using rabbit polyclonal MEF2C Antibody (T300) (RB11009). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MEF2C gene (Lane 2) (Origene Technologies).)

Rabbit anti-Human MEF2C Polyclonal Antibody | anti-MEF2C antibody

MEF2C (T300) (Myocyte-specific Enhancer Factor 2C)

Gene Names
MEF2C; C5DELq14.3; DEL5q14.3
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity Purified
Purified by immunoaffinity chromatography.
Synonyms
MEF2C; Polyclonal Antibody; MEF2C (T300) (Myocyte-specific Enhancer Factor 2C); Anti -MEF2C (T300) (Myocyte-specific Enhancer Factor 2C); anti-MEF2C antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human MEF2C.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Applicable Applications for anti-MEF2C antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
Immunogen
Synthetic peptide corresponding to amino acid residues surrounding T300 of human MEF2C (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of MEF2C (arrow) using rabbit polyclonal MEF2C Antibody (T300) (RB11009). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MEF2C gene (Lane 2) (Origene Technologies).)

Western Blot (WB) (Western blot analysis of MEF2C (arrow) using rabbit polyclonal MEF2C Antibody (T300) (RB11009). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MEF2C gene (Lane 2) (Origene Technologies).)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human brain tissue reacted with MEF2C Antibody (T300), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (Formalin-fixed and paraffin-embedded human brain tissue reacted with MEF2C Antibody (T300), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Related Product Information for anti-MEF2C antibody
MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. This protein controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It may also be involved in neurogenesis and in the development of cortical architecture.
Product Categories/Family for anti-MEF2C antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
51,221 Da
NCBI Official Full Name
myocyte-specific enhancer factor 2C isoform 1
NCBI Official Synonym Full Names
myocyte enhancer factor 2C
NCBI Official Symbol
MEF2C
NCBI Official Synonym Symbols
C5DELq14.3; DEL5q14.3
NCBI Protein Information
myocyte-specific enhancer factor 2C; OTTHUMP00000222409; OTTHUMP00000222410; OTTHUMP00000222411; OTTHUMP00000222412; OTTHUMP00000222542; OTTHUMP00000222543; OTTHUMP00000222544; OTTHUMP00000222656; MADS box transcription enhancer factor 2, polypeptide C
UniProt Protein Name
Myocyte-specific enhancer factor 2C
UniProt Gene Name
MEF2C
UniProt Entry Name
MEF2C_HUMAN

NCBI Description

This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq]

Uniprot Description

MEF2C: transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q14.3

Cellular Component: nucleoplasm; protein complex; intracellular membrane-bound organelle; cytoplasm; nuclear speck; cytosol; nucleus

Molecular Function: protein binding; miRNA binding; transcription activator binding; DNA binding; AT DNA binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: cardiac muscle hypertrophy; muscle development; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; heart development; stress-activated MAPK cascade; regulation of neurotransmitter secretion; regulation of synaptic plasticity; toll-like receptor 3 signaling pathway; toll-like receptor 5 signaling pathway; neuron differentiation; positive regulation of MAP kinase activity; B cell receptor signaling pathway; regulation of neuron apoptosis; positive regulation of B cell proliferation; negative regulation of ossification; chondrocyte differentiation; negative regulation of neuron apoptosis; toll-like receptor 4 signaling pathway; positive regulation of cardiac muscle cell proliferation; endochondral ossification; nervous system development; skeletal muscle development; monocyte differentiation; response to virus; myotube differentiation; positive regulation of skeletal muscle development; muscle cell fate determination; toll-like receptor 2 signaling pathway; muscle cell differentiation; regulation of synaptogenesis; neuron development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; toll-like receptor 9 signaling pathway; B cell proliferation; transcription from RNA polymerase II promoter; regulation of synaptic transmission, glutamatergic; apoptosis; ventricular cardiac muscle cell differentiation; neuron migration; regulation of synaptic activity; negative regulation of transcription from RNA polymerase II promoter; palate development; toll-like receptor 10 signaling pathway; learning and/or memory; B cell homeostasis; regulation of transcription, DNA-dependent; melanocyte differentiation; regulation of megakaryocyte differentiation; germinal center formation; neural crest cell differentiation; heart looping; negative regulation of epithelial cell proliferation; blood vessel development; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; embryonic viscerocranium morphogenesis; positive regulation of bone mineralization; positive regulation of myoblast differentiation; humoral immune response; regulation of germinal center formation; MyD88-dependent toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of osteoblast differentiation; neuron morphogenesis during differentiation; toll-like receptor signaling pathway; positive regulation of muscle cell differentiation; innate immune response; blood vessel remodeling; platelet formation; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation

Disease: Mental Retardation, Autosomal Dominant 20

Research Articles on MEF2C

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Product Notes

The MEF2C mef2c (Catalog #AAA626170) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MEF2C (T300) (Myocyte-specific Enhancer Factor 2C) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MEF2C can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:100 Immunohistochemistry: 1:10-1:50. Researchers should empirically determine the suitability of the MEF2C mef2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MEF2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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