Western Blot (WB)
(Host: RabbitTarget Name: MEF2ASample Tissue: Rat Skeletal MuscleAntibody Dilution: 1ug/ml)
Rabbit MEF2A Polyclonal Antibody | anti-MEF2A antibody
MEF2A antibody - N-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: MEF2ASample Tissue: Rat Skeletal MuscleAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: MEF2ASample Tissue: Rat Skeletal MuscleAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RatTarget Name: MEF2ASample Tissue: Rat Skeletal MuscleAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RatTarget Name: MEF2ASample Tissue: Rat Skeletal MuscleAntibody Dilution: 1ug/ml)
Western Blot (WB)
(WB Suggested Anti-MEF2A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Transfected 293T)
Western Blot (WB)
(WB Suggested Anti-MEF2A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Transfected 293T)
Target Description: The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD, myogenin, MYF5, and MRF4 are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes.The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Description
MEF2A: a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported.
Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q26
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nuclear chromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; protein binding; transcription activator binding; protein heterodimerization activity; sequence-specific DNA binding; histone deacetylase binding; chromatin binding; SMAD binding; transcription factor activity; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; muscle development; ventricular cardiac myofibril development; nerve growth factor receptor signaling pathway; apoptosis; heart development; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; mitochondrial genome maintenance; toll-like receptor 4 signaling pathway; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; dendrite morphogenesis; MAPKKK cascade; toll-like receptor 2 signaling pathway; mitochondrion distribution; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; toll-like receptor signaling pathway; positive regulation of muscle cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway
Disease: Coronary Artery Disease, Autosomal Dominant, 1
Research Articles on MEF2A
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Product Notes
The MEF2A mef2a (Catalog #AAA3201939) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MEF2A antibody - N-terminal region reacts with Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's MEF2A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the MEF2A mef2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: YNEPHESRTN SDIVEALNKK EHRGCDSPDP DTSYVLTPHT EEKYKKINEE. It is sometimes possible for the material contained within the vial of "MEF2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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