Rabbit MED19 Polyclonal Antibody | anti-MED19 antibody

MED19 Rabbit Polyclonal

Cat. Num. AAA7601324

• Gene Names: MED19; LCMR1; DT2P1G7; MED19AS
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MED19; Polyclonal Antibody; MED19 Rabbit Polyclonal; anti-MED19 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 211

• Applicable Applications for anti-MED19 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Mediator complex subunit 19
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis tissue slide using MBS7601324 (MED19 Antibody) at dilution of 1:50)

Western Blot (WB)

(human testis tissue were subjected to SDS PAGE followed by western blot with MBS7601324 (MED19 antibody) at dilution of 1:100)

NCBI and Uniprot Product Information

• NCBI GI #: 952009246
• NCBI GeneID: 219541
• NCBI Accession #: NP_703151.2
• NCBI GenBank Nucleotide #: NM_153450.2
• Molecular Weight: 20,431 Da
• NCBI Official Full Name: mediator of RNA polymerase II transcription subunit 19 isoform 2
• NCBI Official Synonym Full Names: mediator complex subunit 19
• NCBI Official Symbol: MED19
• NCBI Official Synonym Symbols: LCMR1; DT2P1G7; MED19AS
• NCBI Protein Information: mediator of RNA polymerase II transcription subunit 19
• UniProt Protein Name: Mediator of RNA polymerase II transcription subunit 19
• Protein Family: Putative mediator of RNA polymerase II transcription
• UniProt Gene Name: MED19
• UniProt Synonym Gene Names: LCMR1
• UniProt Entry Name: MED19_HUMAN

NCBI Description

The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

MED19: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 19 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: nucleus; Srb-mediator complex

Molecular Function: protein binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent