Rabbit MECR Polyclonal Antibody | anti-MECR antibody
MECR Rabbit pAb
Gene Names
MECR; NRBF1; CGI-63; FASN2B
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Affinity purified
Synonyms
MECR; Polyclonal Antibody; MECR Rabbit pAb; mitochondrial trans-2-enoyl-CoA reductase; ETR1; NRBF1; CGI-63; FASN2B; DYTOABG; anti-MECR antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purified
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
1.2mg/ml (varies by lot)
Applicable Applications for anti-MECR antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
WB: 1:1000-1:5000
IHC-P: 1:50-1:300
IHC-P: 1:50-1:300
Immunogen
Fusion protein of human MECR
Conjugation
Unconjugated
Modification
Unmodified
Preparation and Storage
Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.
Western Blot (WB)
(Western Blot analysis of MECR in Human fetal brain tissue lysate using MECR Rabbit pAb at dilution 1/1000)
Immunohistochemistry (IHC)
(Immunohistochemistry of MECR in paraffin-embedded Human breast cancer tissue using MECR Rabbit pAb at dilution 1/70. Predicted cell location: Nucleus)
Related Product Information for anti-MECR antibody
The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32,228 Da
NCBI Official Full Name
trans-2-enoyl-CoA reductase, mitochondrial isoform b
NCBI Official Synonym Full Names
mitochondrial trans-2-enoyl-CoA reductase
NCBI Official Symbol
MECR
NCBI Official Synonym Symbols
NRBF1; CGI-63; FASN2B
NCBI Protein Information
trans-2-enoyl-CoA reductase, mitochondrial; homolog of yeast 2-enoyl thioester reductase; mitochondrial 2-enoyl thioester reductase; nuclear receptor binding factor 1
UniProt Protein Name
Trans-2-enoyl-CoA reductase, mitochondrial
UniProt Gene Name
MECR
UniProt Synonym Gene Names
NBRF1; HsNrbf-1; NRBF-1
UniProt Entry Name
MECR_HUMAN
Uniprot Description
MECR: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - fatty acid elongation in mitochondria; Oxidoreductase; EC 1.3.1.38
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component: mitochondrion; nucleus
Molecular Function: zinc ion binding; trans-2-enoyl-CoA reductase (NADPH) activity
Biological Process: fatty acid metabolic process; fatty acid biosynthetic process
